胆管癌组织中LRP/P170基因的表达及其临床意义  

Expression of multidrug resistance-related proteins LRP/P170 in cholangiocarcinoma and its clinnical significance

作　　者：安杰[1] 刘伟[2] 侯会池[2] 

机构地区：[1]北京军区白求恩国际和平医院病理科,河北石家庄050082 [2]北京军区白求恩国际和平医院普通肝胆外科,河北石家庄050082

出　　处：《中国现代普通外科进展》2011年第4期257-259,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨胆管癌组织中LRP和P170的基因表达情况及其临床意义。方法:收集手术切除的胆管癌标本21例作为实验组,另取8组胆管炎症标本作为对照组,采用RT-PCR方法检测标本中LRP及P170 mRNA的表达。结果:LRP及P170 mRNA在胆管癌组织中的表达阳性率分别76.2%和66.7%,显著高于对照组(P<0.05),上述指标与性别、年龄、病理分期、分化程度、淋巴结转移均无关(P>0.05)。结论:LRP及P170在未经过化疗的胆管癌组织中均有不同程度的高表达;胆管癌的原发性多药耐药可能与LRP及P170有关。Objective： Multidrug resistance is the main cause for the patients with cholangiocarcinoma for not responding to chemotherapy.The expression of lung resistance protein（LRP）,glutathione P-glycoprotein（P170） were investigated in cholangiocarcinoma.Methods： The expression of LRP and P170 in 21 cases of cholangiocarcinoma were measured by RT-PCR methods,while 8 cases of choledochitis served as the control group.Results： The positive rate of LRP,P170 mRNA in cholangiocarcinoma were 76.2%,66.7% respectively,significantly higher than those of control group（P0.05）.Their expressions were not related to gender,age,staging,differentiation and lymph node metastasis（P0.05）.Conclusion： LRP and P170 were overexpressed in various degrees in cholangiocarcinoma without chemotherapy,and may be related to the primary multidrug resistance of the tumors.

关 键 词：胆管肿瘤 多药耐药相关蛋白质类 肺耐药蛋白 P-糖蛋白 

分 类 号：R735.8[医药卫生—肿瘤]