安理申治疗老年性痴呆的疗效观察  

作　　者：陈伟鑫 

机构地区：[1]广州市海珠区红十字会医院,521011

出　　处：《当代医学》2011年第16期149-150,共2页Contemporary Medicine

摘　　要：目的探讨安理申治疗老年性痴呆的临床疗效。方法选择2009年1月～2010年1月在住院及门诊治疗的70例老年性痴呆患者,随机分为治疗组和对照组各35例,治疗组应用安理申治疗,并辅助以哈伯因、脑复康等,对照组只用哈伯因、脑复康等而不用安理申,比较两组疗效、症状改善及不良反应。结果治疗组总有效率为88.6%,对照组总有效率为68.6%,两组差异有统计学意义(P<0.05);两组治疗前MMSE和ADL评分并无明显差别,治疗后MMSE评分均增加,ADL评分均降低,与治疗前比较差异均有统计学意义(P<0.05),但治疗组评分变化幅度要大于对照组,从两组治疗后的评分比较来看,治疗组MMSE评分高于对照组,而ADL评分低于对照组,差异均有统计学意义(P<0.05);治疗组不良反应发生率为17.1%,对照组为14.3%,两组比较差异无统计学意义(P>0.05)。结论安理申治疗老年性痴呆疗效确切,值得在临床推广应用。Objective To explore the clinical effect of donepezil to treat alzheimer disease.Methods 70 AD patients were selected in our hospital from January 2009 to January 2010,and were randomly divided into treat group and control group with 35 patients in each group;the treat group were treated with donepezil,huperzine and piracetam,the control group were treated only with huperzine and piracetam,their effect,symptoms improve and adverse reaction were compared.Results Total effect of the treat group was 88.6%,which of the control group was 68.6%,the difference is statistical significant（P0.05）,MMSE and ADL score of the two groups before treating had no obvious difference,MMSE score increased and ADL score decreased after treating,and the difference was statistical signif icant（P0.05）compare with before treating,but the treat group changed much more than the control group,MMSE score of the treat group was higher than the control group while ADL score was lower than the control group（P0.05）;adverse reaction rate of the treat group was 17.1%,which of the control group was 14.3%,the difference had no statistical significant（P0.05）.Conclusion It has good effect of using donepezil to treat alzheimer disease,and can be widely used in clinic.

关 键 词：安理申 老年性痴呆 哈伯因 脑复康 

分 类 号：R749.1[医药卫生—神经病学与精神病学]