载脂蛋白E基因多态性与胆石病关系的Meta分析  

A meta-analysis of the association of apoE gene polymorphisms and gallstone

作　　者：刘照国[1] 宋文渊[1] 吕明[1] 张勇[1] 符国珍[1] 

机构地区：[1]中南大学湘雅医学院附属海口医院肝胆外科,海口570208

出　　处：《中华肝胆外科杂志》2011年第5期397-400,共4页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的探讨载脂蛋白E（apoE）基因多态性与胆石病的关系。方法全面检索和筛选相关文献，通过Meta分析的方法对各研究结果进行数据合并，并评价其发表偏倚，运用敏感性分析评价结果的可靠性。结果检索到相关文献11篇，包括1248例胆石病患者，1660例对照组。Meta分析研究发现，apoE等位基因ε4以及基因型E3／E4在胆石病患者中的分布频率明显高于对照组。其合并OR值及95％的CI（可信区间）分别是1．32（1．01～1．71）、1．60（1．04～2．46），Pd0．05。发表性偏倚和敏感性分析显示部分存在发表偏倚，但稳定性较好。结论胆石病与apoE基因的多态性密切相关，等位基因ε4以及基因型E3／E4是胆石病的危险因子。Objective To evaluate the relationship between apoE gene polymorphisms and gall- stone. Methods We included all the published studies on the association between apoE gene polymor- phisras and gall-stone. A meta-analysis was employed to summarize all these studies, calculate the pooled OR and its 95 % confidence interval （95 % CI）, and test the overall effects. The Egger＇s publication bias analysis and sensitivity analysis were carried out to evaluate the reliability and stability of the meta-analysis. Results Eleven association studies between the apoE gene polymorphisms and gall- stone fulfilled our inclusion criteria. There were 1248 patients with gallstones and 1660 controls. Remarkable heterogeneities were discovered in the allele ε4 and genotype E3/E4 of apoE between gall- stone and control subjects in these studies （P〈0.05）. Their ORs and 95%CIs were 1.32 （1.01, 1.71）, 1.60 （1.04, 2.46）, respectively （P〈0.05）. The results of sensitivity analysis and publication bias analysis showed the reliability and stability of this meta-analysis. Conclusion apoE gene pol ymorphisms are associated with gallstone. Those with the alleleε4 or genotype E3 /E4 had a higher risk of suffering from gallstone.

关 键 词：胆石病 载脂蛋白E 基因多态性 META分析 

分 类 号：R575.62[医药卫生—消化系统]