归脾汤对抑郁模型小鼠血清中IL-4的影响  

Effect of Guipi Decoction on Depression Model Mice Serum IL-4

作　　者：新昕[1] 季颖[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032

出　　处：《实用中医内科杂志》2011年第5期41-42,共2页Journal of Practical Traditional Chinese Internal Medicine

摘　　要：[目的]观察比较各组小鼠的行为学症状表及血清中IL-4的含量,观察归脾汤对抑郁模型小鼠抑郁症状和免疫功能的影响。[方法]将36只小鼠,随机分为空白组、模型组、中药组和西药组,每组9只。除空白组外,其他组均给予21天慢性不可预见性应激造模。与此同时,模型组灌服生理盐水,中药组和西药组给药治疗。处死后取血,测定小鼠血清中的IL-4的含量。[结果]模型组旷场试验的跨格数和直立数均明显低于空白组(P<0.05);IL-4含量,模型组与空白组比较显著降低(P<0.05),中药组与空白组比较(P>0.05),中药组与模型组和西药组比较(P<0.05)。[结论]归脾汤对调节抑郁状态和调节应激状态下的免疫功能有积极作用,能有效提升因抑郁引起的IL-4含量的减低。[Objective]To observe and study compares in each group of mouse＇s symptom on behavior and the content of IL-4 in blood serum,to study Guipi Decoction＇s function in behavior and immunization of depression mouse.[Method]36 mice,stochastically divides into blank group,model group,Traditional Chinese Mmedicine（TCM） group and western medicine group,each group of 9.Except blank group,other groups give 21 day of chronic unpredictability stimulation to make the mold.Meanwhile,the model group fills the physiological saline,TCM group and the western medicine group have medicine treatment.After the execution,draws blood,determinat mouse blood serum＇s IL-4 content.[Results]Model groupopen field test＇s behavior scores and IL-4 content are obviously lower than the blank group（P0.05）;about IL-4 content,model group is quite remarkable reduce than the blank group（P0.05）.Between TCM group and the control group there is no significant difference（P0.05）,TCM group is better than model group and western medicine group,there is significantly statistically significant（P 0.05）.[Conclusion]Guipi Decoction has a positive effecton on depression and regulation the fuction of immunization under stress,can effectively enhance the reduced content of IL-4 caused by depression.

关 键 词：抑郁症 归脾汤 IL-4 

分 类 号：R-33[医药卫生]