宫颈癌及其癌前病变组织中端粒酶逆转录酶的表达及意义  

Expression and the Significance of Telomerase hTERT in Cervical Carcinomas and Precancerous Lesions

作　　者：张娟娟[1] 陈永平[2] 吴秀霞[1] 

机构地区：[1]广东省深圳市第五人民医院妇产科,518001 [2]广东省深圳市第五人民医院病理科,518001

出　　处：《医学信息（下旬刊）》2011年第5期60-60,共1页Medical information

基　　金：本课题为深圳市科技计划项目（项目编号200603186）

摘　　要：目的：通过检测宫颈癌及其癌前病变组织中端粒酶逆转录酶（human telomerase reverse transcriptase,hTERT）的表达,探讨其作为宫颈癌标志物及其在评价宫颈癌前病变组织癌变趋势的价值.方法：采用原位杂交技术检测20例宫颈癌、32例宫颈癌前病变组织（宫颈上皮内瘤样病变,CIN）、20例慢性宫颈炎病理存档石蜡包埋组织hTERT的表达.结果：各组的hTERT的阳性率依次为：宫颈癌〉CINⅢ级〉CINⅠ、Ⅱ级〉慢性宫颈炎,其中宫颈癌90.0%（18/20）,CIN 63.0%（20/32）,慢性宫颈炎15.0%（3/20）,各组之间阳性率比较,差异有显著性（P〈0.05）.结论：采用原位杂交技术检测hTERT高表达可能成为宫颈癌标志物,追踪hTERT阳性的子宫颈癌前病变患者可能有助于早期发现宫颈癌.Objective To investigate the expression and the Significance of telomerase hTERT in cervical carcinomas and precancerous lesions. Method hTERT mRNA expressions in 20 cases of cervical carcinoma , 32 cases of CIN and 20 cases of chronic cervicitis was detected by in situ hybridization. Results The positive rates of hTERT mRNA in cervical carcinoma,CIN and chronic cervicitis were 90.0%（18/20）, 63.0%（20/32）, 15.0% （3/20） , respectively. There was significant statistical difference （P〈0.05） . With the development of cervical lesion, the expressions of hTERT mRNA was increasing. Conclusion The results indicate that increased hTERT expression might be a useful marker for diagnosis of cervical carcinoma and a effectively tool for predicting the malignant change potential of cervical precancerous lesions.

关 键 词：端粒酶逆转录酶 原位杂交 宫颈肿瘤 癌前状态 子宫颈上皮内瘤样病变 

分 类 号：R737.3[医药卫生—肿瘤]