奈达铂联合氟尿嘧啶治疗晚期食管癌的疗效观察  

Observation on the efficacy of nedaplatin combined with 5-fluorouracil in treatment of advanced esophageal cancer

作　　者：刘永玲 

机构地区：[1]淮南东方医院集团肿瘤医院肿瘤科,安徽省淮南232035

出　　处：《中国基层医药》2011年第12期1641-1643,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 比较奈达铂（NDP）与顺铂（DDP）联合氟尿嘧啶（5-Fu）对晚期食管癌的疗效及其不良反应.方法 61例晚期食管癌患者随机为分观察组（奈达铂组）30例,对照组（顺铂组）31例.奈达铂组给予NDP 80～100 mg/m2,静脉滴注,第1天,5-Fu 0.5 g/m2,静脉滴注,第1～5天 顺铂组给予DDP 80～100 mg/m2,分3 d静脉滴注,5-Fu 0.5 g/m2静脉滴注,第1～5天.每4周为一个化疗周期,2个化疗周期后评定疗效并比较.结果 观察组有效率56.7%,显著高于对照组的29.0%（P〈0.05） 观察组的胃肠道不良反应显著低于对照组（P〈0.05）,但骨髓毒性显著高于对照组（P〈0.05）.结论 NDP联合5-Fu对晚期食管癌有一定的疗效,较DDP联合5-Fu方案有一定优势,临床耐受性较好,可作为一线药物推荐.Objective To compare the efficacy of nedaplatin（NDP） and cisplatin（ DDP） combined with 5-fluorouracil（S-Fu） in treatment of advanced esophageal cancer.Methods 61 patients with advanced esophageal cancer were divided into two groups randomly,the observation group（NDP group） were 30 cases and the control group （DDP group） were 31 cases.NDP group were given NDP（80 ～ 100mg/m2, intravenous drip, 1 day） and 5-Fu （0.5g/m2,intravenous drip,l～5 day） ,DDP group were given DDP（80 ～100mg/m2 ,devided into 3 days） and5-Fu （ 0.5 g/m2 , intravenous drip ,1～5 day）.The cycles were repeated every 4 weeks, and the effects were assessed after 2 cycles.Results The remisson rate of the observation group was 56.1% ,significantly higher than that of the control group （29.0% ） （ P 〈0.05）.The toxicity of the observation group was milder for gastrointestinal tract but more serious for bone marrow than that of the control group （all P 〈 0.05）.Conclusion NDP was an effective platinum drug for esophageal carcinoma.The efficacy of nedaplatin combined with 5-Fu regimen was better than that of DDP combined with 5-Fu regimen,and it had a good clinical tolerance and could be recommended as the first-line drugs.

关 键 词：食管肿瘤 奈达铂 顺铂 

分 类 号：R735[医药卫生—肿瘤]