老年期抑郁症抗抑郁药物治疗前后感觉门控P50改变  

Change of auditory evoked potential P50 in Senile depression before and after anti-depression treatment.

作　　者：刘群[1] 沈丽峰[2] 李亚玲[2] 唐云翔[3,4] 

机构地区：[1]上海市民政第三精神卫生中心精神科,上海200436 [2]浙江省嘉兴市康慈医院,嘉兴314500 [3]第二军医大学心理学教研室 [4]上海交通大学医学院附属上海市精神卫生中心

出　　处：《中国神经精神疾病杂志》2011年第5期266-268,共3页Chinese Journal of Nervous and Mental Diseases

基　　金：上海市民政局科研项目(2010)

摘　　要：目的探讨老年期抑郁症的感觉门控(Sensory Gating,SG)P50特征及其在抗抑郁治疗后的变化。方法采用条件刺激(S1)-测试刺激(S2)模式对38例老年期(发病年龄>60岁)抑郁症患者和正常对照组的42名健康老人进行P50检测,前者在给予帕罗西汀20mg/d治疗16个月末再次检测。使用17项汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD17)评估患者治疗前后的抑郁症状。结果与正常对照组比较,患者组S2-P50波幅增高[(2.89±1.02)μV vs(1.30±1.07)μV,P<0.01)],潜伏期延迟[(64.14±14.69)ms vs(55.92±17.73)ms,P<0.05)],提示P50抑制明显减弱;与治疗前相比,患者组在治疗16个月末的所有P50指标均无明显改变(P>0.05)。治疗前后感觉门控P50指标S2/S1、S1-S2和100(1-S2/S1)与HAMD17分值无相关(P>0.05)。结论老年期抑郁症患者感觉门控抑制存在明显缺损,具有跨状态稳定性,可能为素质性。Objective To characterize the sensory gating（SG） of P50 in senile depression（SD） and investigate its change before and after Paroxetine treatment.Methods P50 were elicited in 38 Senile depression and 42 normal controls（NC）using a paradigm of S1（a conditioning stimulus）-S2（test stimulus）.After 16 months of Paroxetine（20mg/d） treatment,P50 were re-tested in patients.Hamilton depression Scale（HAMD17） were used to assess the depression symptom in patients.Results Compared with NC,SD patients had a obvious deficit in P50 suppression as evidence by increased amplitude（SD：2.89±1.02,NC： 1.30±1.07,P0.01） and prolonged latency（SD： 64.14±14.69,NC： 55.92±17.73,P0.05） of S2-P50.There were no significant correlations of the S2/S1 ratio,S2-S1,and 100（1-S2/S1） with HAMD17 before and after the treatment（P0.05）.There was no significant difference in all P50 indexes in SD patients before and after 16 months of Paroxetine treatment（P0.05）.Conclusions SD patients have obvious deficit of sensory gating and the deficit is not affected by anti-depression treatment,suggesting the deficit may be a trait marker for SD.

关 键 词：感觉门控 P50 老年期抑郁症 健康老人 帕罗西汀 

分 类 号：R749.4[医药卫生—神经病学与精神病学]