早产儿视网膜病变激光光凝治疗后视网膜功能发育状况观察  

Development rod and cone functions in retinopathy of prematurity after laser photocoagulation

作　　者：贾洪娟[1] 项道满[1] 毛娅妮[1] 刘恬[1] 陈锋[1] 胡兰香[1] 杨远慧[1] 

机构地区：[1]广州医学院附属广州市妇女儿童医疗中心眼科,广州510623

出　　处：《中华眼底病杂志》2011年第3期267-270,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：广东省社会发展领域科技计划项目（83036）;广州市科技攻关计划重大项目（200521-E0102）

摘　　要：目的观察早产儿视网膜病变（ROP）患儿视网膜激光光凝治疗后的视网膜功能发育状况。方法对30例患阈值期ROP并成功接受视网膜激光光凝治疗的早产儿（病例组）和30例无ROP早产儿（对照组）进行闪光视网膜电图（F—ERG）检查，记录视杆细胞反应、视锥细胞反应、最大混合反应及振荡电位。结果与对照组比较，病例组视杆细胞反应振幅明显降低（t=-2．385）、潜伏期明显延长（t=-2．799），差异有统计学意义（P〈O．05）；最大混合反应a、b波振幅降低，与对照组比较，差异有统计学意义（t=-2．967，-4．037；P〈0．05）；两组间最大混合反应的b／a波振幅比值（t=-1．402）、潜伏期（t=-1．637，0．465）比较，差异无统计学意义（P〉0．05）。两组间视锥细胞反应a波潜伏期（t=1．222，）和振幅（t=-o．636）、b波振幅（t=-1．927）比较，差异无统计学意义（P〉o．05）。病例组视锥细胞反应b波潜伏期较对照组延长，差异有统计学意义（t=-2．296，P〈0．05）；振荡电位幅值较对照组降低，差异有统计学意义（t=-2．466，P％0．05））。结论ROP患儿激光光凝治疗后，视网膜视锥细胞功能发育与正常早产儿无差异，视杆细胞功能发育落后于正常早产儿。Objective To observe the development of cone/rod functions in children with retinopathy of prematurity （ROP） after laser photocoagulation. Methods 30 ROP patients （60 eyes） treated with laser photoeoagulation （case group） and 30 preterm infants （60 eyes） without ROP （control group） were enrolled in this study. Flash Electroretinogram （F-ERG） was performed on all the children, and the response of rod cells and cone cells, maximal mixed responses and oscillatory potentials were recorded. Results Compared with the control group, the amplitude of response of rod cells was obviously decreased （t= -2. 385, P〈0.05）, while the latency phase of rod cells was obviously prolonged （t = -2. 799, P〈0.05）~ the amplitudes of a-and b-wave of maximal response were significantly decreased in the case group （t= -2. 967, -4. 037;P〈0.05）. But there was no significant difference of amplitudes（t=-1. 402） and latency phase （t= -1. 637,0. 465）ot b-/a-wave of the maximal mixed response between two groups（P〉0.05）. In the response of cone cells, there was no significant difference of the latency phase （t= 1. 222） and amplitude （t= -0. 636）of a-wave as well as amplitude （t= -1. 927） of b-wave between two groups （P〉0.05）. The latency phase of b-wave of cone cells in the case group was longer than that in the control group （t = -2. 466, P〈0.05）. Conclusions Compared to no-ROP preterm infant retina, laser-treated ROP retina has normal cone function development and delayed rod function development.

关 键 词：视网膜病 早产儿 视网膜/生长和发育 视网膜电描记术 激光凝固术 

分 类 号：R774.1[医药卫生—眼科]