胃黏膜相关淋巴组织淋巴瘤的治疗策略  

Advance in non-surgical treatment of gastric MALT lymphoma

作　　者：李月敏[1] 张伟京[2] 蒲永东[1] 

机构地区：[1]解放军第三零九医院肿瘤放疗科,北京100091 [2]军事医学科学院附属三零七医院全军肿瘤中心,北京100071

出　　处：《中华肿瘤防治杂志》2011年第5期390-393,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：中国博士后科学基金(20090461439)

摘　　要：目的:总结国内外对胃黏膜相关淋巴组织(MALT)淋巴瘤的病因学、诊断和治疗的最新进展。方法:应用检索MDELINE及CHKD期刊全文数据库检索系统,以"黏膜相关淋巴瘤"和"胃淋巴瘤"为关键词。纳入标准:1)胃MALT淋巴瘤的病因学和基因病理学特征;2)胃MALT淋巴瘤临床特征和分期;3)胃MALT淋巴瘤的治疗。共纳入分析23篇参考文献。结果:H.Pylori感染是胃MALT淋巴瘤的主要病因,抗感染治疗可以使近80%H.Pylori阳性胃MALT淋巴瘤完全消退。因此,抗感染治疗成为早期胃MALT淋巴瘤的标准一线治疗。抗感染无效或复发的患者可以采取放疗、化疗和分子靶向治疗等综合治疗手段。结论:过去人们对胃MALT淋巴瘤常常行手术切除,术后辅助化疗或放疗。但随着近年来对其病因学和生物学行为的认识,目前治疗以非手术治疗为主,目的是保全器官功能,提高患者生活质量。OBJECTIVE： To summarize the advance in the etiolo- gy, diagnosis and treatment of gastric mucosa associated lymphoid tissue（MALT） lymphoma. METHODS： A computer-based online search of Medline and CHKD database was undertaken for literature about gastric MALT lymphoma published with the key words of ＂gastric lymphoma＂and ＂ MALT lymphoma＂. Inclusive criteria： 1 ）Etiology and molecular genetic pathological characteristics of gastric MALT lymphoma. 2）Clinical characteristics and stages of gastric MALT lymphoma. 3）Treatment of gastric MALT lymphoma. Twenty-three reference articles were analyzed. RESULTS： H. Pylori infection is the main cause of gastric MALT lymphoma, eradication of H pylori with antibiotics alone resulted in complete regression of gastric MALT lymphoma in nearly 80% of cases. Therefore, eradication of Helicobacter pylori （H. pylori） is nowadays the standard first-line treatment for early gastric MALT lymphoma. Chemotherapy, radiotherapy and molecular targeted drugs are selective to patients with invalid or recurrent low-grade MALT lymphoma after H. Pylori eradication. CONCLUSIONS： The role of gastrectomy followed by adjuvant chemotherapy and radiotherapy has been prominent in gastric MALT lymphoma treatment in the past. But with the development of aetiological and biological character istics of gastric MALT lymphoma, more and more people support the non-surgical method to improve life quality and preserve the gastric function.

关 键 词：黏膜相关淋巴瘤 胃淋巴瘤 综述文献 

分 类 号：R735.2[医药卫生—肿瘤]