生物材料聚(乳酸-天冬酰胺)的制备与表征  

Synthesis and Characterization of Biomaterial Poly(Lactic Acid-co-Asparagine)

作　　者：叶瑞荣[1] 罗时荷[1] 汪朝阳[1] 谭越河[1] 

机构地区：[1]华南师范大学化学与环境学院,广东广州510006

出　　处：《高分子材料科学与工程》2011年第5期141-144,共4页Polymer Materials Science & Engineering

基　　金：广东省自然科学基金资助项目(5300082);国家自然科学基金资助项目(20772035)

摘　　要：以氯化亚锡为催化剂,L-乳酸(LA)与天冬酰胺(Asn)直接熔融聚合,所得生物材料聚(乳酸-天冬酰胺)[P(LA-co-Asn)]用[η]、红外光谱(FT-IR)、核磁共振(1H-NMR)、凝胶渗透色谱(GPC)、差示扫描量热分析(DSC)、X射线衍射(XRD)等方法进行表征。随着投料比中Asn增加,共聚物由结晶性逐渐转变为无定型态,M-w逐渐降低(9,500～2,700),但能满足药物缓释要求。该合成方法经济、简单易行。与具有一定分支结构的聚(乳酸-天冬氨酸)相比,新型直链共聚物P(LA-co-Asn)侧链中伯酰胺可望进一步结合生物活性分子以改善聚乳酸的生物相容性。Catalyzed by SnCl2,a novel biomaterial poly（lactic acid-co-asparagine）[P（LA-co-Asn）] was directly synthesized via the melt copolycondensation of L-lactic acid（LA） and asparagine（Asn）.The copolymer was systematically characterized with intrinsic viscosity [η],FT-IR,1H-NMR,GPC,DSC and XRD measurements.Increasing the Asn content in the feed,w of the copolymer gradually became smaller,and the crystallinity gradually disappeared.P（LA-co-Asn） with w from 9,500 to 2,700 were obtained,which could meet the demand of drug delivery carrier material.The novel direct copolycondensation method was cheap and practical.Compared with the branched poly（lactic acid-co-aspartic acid）,the pendent primary amide groups in the side chain of the novel linear copolymer P（LA-co-Asn） may be further modified by bioactive molecules,which will be more beneficial to improve biocompatibility of polylactic acid（PLA）.

关 键 词：乳酸 天冬酰胺 聚(乳酸-co-天冬酰胺) 熔融聚合 生物医学材料 

分 类 号：R318.08[医药卫生—生物医学工程]