卵巢浆液性癌患者血清nidogen-2和糖类抗原125的检测及其临床意义  

Clinical significance of serum nidogen-2 and carbohydrate antigen 125 in patients with ovarian serous cystadenocarcinoma

作　　者：陈燕[1] 金平[1] 张洪秀[1] 杨兰生[2] 冯颖[2] 

机构地区：[1]兰州大学第一医院妇产科,兰州730000 [2]兰州大学第一医院病理科,兰州730000

出　　处：《肿瘤》2011年第4期339-342,共4页Tumor

基　　金：中国科学院"西部之光"人才培养计划资助项目[编号:科发人教字(2009)24号]

摘　　要：目的:探讨卵巢浆液性癌患者血清nidogen-2和糖类抗原125(carbohydrate antigen125,CA125)的检测及其临床意义。方法:应用ELISA法和化学发光法分别检测15例卵巢正常者、22例卵巢浆液性囊腺瘤患者和40例卵巢浆液性囊腺癌患者血清nidogen-2和CA125水平。结果:卵巢浆液性囊腺癌患者血清nidogen-2水平明显高于卵巢正常者和卵巢浆液性囊腺瘤患者(P<0.05),卵巢正常者和卵巢浆液性囊腺瘤患者血清nidogen-2水平无明显差异;Ⅲ～Ⅳ期卵巢浆液性囊腺癌患者的血清nidogen-2水平明显高于Ⅰ～Ⅱ期患者(P<0.05)。Nidogen-2和CA125联合检测可提高卵巢浆液性囊腺癌诊断的灵敏度和特异度。结论:Nidogen-2有望成为一种新的卵巢浆液性癌的标志物。Objective：To evaluate the clinical significance of serum nidogen-2 and carbohydrate antigen 125（CA125） in patients with ovarian serous carcinoma.Methods：The serum levels of nidogen-2 and CA125 were determined by ELISA and chemiluminescent assay in 15 cases of normal ovary,22 cases of ovarian serous cystadenoma,and 40 cases of ovarian serous cystadenocarcinoma.Results：Compared with the normal ovary and ovarian serous cystadenoma,the serum level of nidogen-2 was higher in cases of ovarian serous cystadenocarcinoma（P0.05）.The difference of serum nidogen-2 level between the cases of normal ovary and ovarian serous cystadenoma was not significant.The cases of ovarian serous cystadenocarcinoma at Ⅲ-Ⅳ stages had a higher serum nidogen-2 level than those at Ⅰ-Ⅱ stages（P0.05）.The diagnostic sensitivity and specificity were both improved by combined detection of serum nidogen-2 and CA125.Conclusion：Serum nidogen-2 can be used as a new biomarker for ovarian serous cystadenocarcinoma.

关 键 词：卵巢肿瘤 肿瘤标记 生物学 CA-125抗原 Nidogen-2 

分 类 号：R737.31[医药卫生—肿瘤]