β-catenin、cyclinD1在胸腺肿瘤中的表达及意义  

Expression and Significance of β-catenin and CyclinD1 in Thymic Tumor

作　　者：赵荣磊[1] 徐林浩[1] 沈毅[1] 江玉华[1] 李发恩[1] 

机构地区：[1]青岛大学医学院附属医院胸外科,山东青岛266003

出　　处：《现代生物医学进展》2011年第9期1737-1740,共4页Progress in Modern Biomedicine

摘　　要：目的:研究β-catenin、cyclinD1在胸腺肿瘤的表达及其意义。方法:采用免疫组化pv6000法检测69例胸腺肿瘤中β-catenin及cyclinD1的表达。结果:β-catenin与cyclinD1在胸腺肿瘤中的阳性表达率均为(53.62%)明显高于正常胸腺组织(0%)(P=0.027)。β-catenin的阳性表达的差异在A、AB、B1、B2、B3及C型胸腺肿瘤各型之间存在统计学意义(X2=24.676,P<0.01)。其表达的在A、AB及B1型与B2、B3及C型(无/低度危险组肿瘤与中/高度危险组肿瘤)之间表达的差异存在统计学意义(X2=21.955,P<0.01)。CyclinD1在A、AB、B1、B2、B3及C型胸腺肿瘤中的阳性表达的差异存在统计学意义(X2=14.393,P=0.013)。其表达在A、AB及B1型与B2、B3及C型(无/低度危险组肿瘤与中/高度危险组肿瘤)之间表达的差异存在统计学意义(X2=10.470,P=0.001)。在胸腺肿瘤中,β-catenin的表达与cyclinD1表达呈正相关关系(r=0.449,P<0.01)。结论:β-catenin、cyclinD1对于判定胸腺肿瘤的恶性程度可能有重要的参考价值。Wnt/β-catenin信号传导通路在胸腺肿瘤的发生过程中可能发挥重要作用。Objective： The objective of this experiment is to explore the expression and significance of β-catenin and cyclinD1 in thymic tumor. Methods： Immunohistochemical pv6000 was used to detected the expression of β-catenin and cyclinD1 in 69 cases of thymic tumor. Results： The positive expression ratio of β-catenin and cyclinD1in thymic tomor both were 53.26%,which were signifi- cantly higher than of normal thymus（0%）（P=0.027）. The positive expression ratio of β-catenin in thymic tomor were significantly differ- ent among type A,AB,B1,B2,B3 and C of thymic tumor （X2=24.676,P0.01）. The positive expression ratio of β-catenin was significantly higher in B2,B3 and C types than in A,AB,and B1 types （X2=21.955,P0.01）. The positive expression ratio of cyclinD1 in thymic tomor were significantly different among type A,AB,B1,B2,B3 and C of thymic tumor （X2=14.393,P=0.013）. The positive expression ratio of cyclinD1 was significantly higher in B2,B3 and C types than in A,AB,and B1 types（X2=10.470,P0.01）. The expression of β-catenin can be positively corelated with that of cyclinD1（r=0.449,P0.01）. Conclusion： β-catenin and cyclinD1 maybe have important reference val- ue for determining the malignancy of thymic tumors.Wnt/β-catenin signaling pathway may play important roles in the tumorigenesis of thymic tumors.

关 键 词：Β-CATENIN CYCLIND1 胸腺肿瘤 免疫组化 

分 类 号：R734.5[医药卫生—肿瘤] R655.7[医药卫生—临床医学]