The expression of ras-p21 and p53 protein in inguinal lymph nodes and clinical significance with penile cancer  

Ras-p21,p53在阴茎癌腹股沟淋巴结中的表达及临床意义(英文)

作　　者：Jianguang Liu Feng Yue Jinyi Yang Wei Wei Xiaomin Wang 

机构地区：[1]Department of Urology, The Friendship Hospital of Dalian, Dalian 116001, China [2]Department of Urology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2011年第6期337-339,共3页中德临床肿瘤学杂志（英文版）

摘　　要：Objective: The aim of this study was to investigate the expression and clinical significance of ras-p21 and p53 proteins in inguinal lymph nodes with penis carcinoma. Methods: The clinical data of 44 patients of penis (squamous) carcinoma and 40 non-tumor patients from 1990 to 2002 in our hospital were added to our research, 84 inguinal lymph nodes were got by lymph node biopsy from each patient at random. Pathological examination showed that 18 cases of cancer group were metastatic carcinoma as group A, the other 26 cases were inflammatory affection as group B. 20 cases of non-tumor group were nonspecific inflammatory inguinal lymph nodes as group C and the other 20 cases were normal lymph nodes as group D, all the 84 cases in our research were investigated by immunohistochemistry to detect the expression of ras-p21 and p53 protein. Results: Immunohistochemistry demonstrated that the expression of as-p21 and p53 protein were significantly higher in cancer group A (88.89%, 72.22%) and B (30.77%, 23.08%) than in control group C (5%, 0%) and group D (0%, 0%.). The expression of two proteins showed significant differences between group A and group B (P < 0.01), and no significant differences between group B and group C (P > 0.05). The expression of two proteins showed significant difference between group A and control group (C + D) (P < 0.01). The expression of two proteins showed significant differences between cases of cancer groups (A + B) and control groups (C + D) (P < 0.01). Significant differences were showed between group (A + B) and group D with the expression of ras-p21 and p53 (P < 0.01). The expression of ras-p21 and p53 in three different differentiated groups were G1 (well-differentiated) group: (22.73%, 13.64%), G2 (moderate-differentiated) group: (81.25%, 68.75%), G3 (poorly differentiated) group: (100%, 83.33%). There was significant differences between G1 group and G3 group (P < 0.05), and no significant differences between G1 group and G2 group, G2 group and G3 group (P > 0.05). There was signific

关 键 词：penis carcinoma inguinal lymph nodes IMMUNOHISTOCHEMISTRY INFLAMMATION 

分 类 号：Q71[生物学—分子生物学] S851.43[农业科学—预防兽医学]