GDNF基因多态性与精神分裂症临床特征的相关性  

Correlation between clinical characteristics of schizophrenia and gene polymorphisms of glial cell line-derived neurotrophic factor

作　　者：马雪红[1,2] 高成阁[1] 王宝安[2] 翟歆明 胡晓刚[2] 李生斌[3] 刘清波[3] 

机构地区：[1]西安交通大学医学院第一附属医院精神科,陕西西安710061 [2]宝鸡市康复医院,陕西宝鸡721001 [3]西安交通大学医学院法医系,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2011年第3期307-310,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：陕西省科学技术研究发展计划项目(No.2007K15-03)~~

摘　　要：目的探讨GDNF基因多态性与精神分裂症临床特征的相关性。方法对符合纳入标准的精神分裂症病例组及健康对照组进行临床资料收集及血样的采集,采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法检测GDNF基因多态性。选取GDNF基因2个SNP位点:rs2973050,rs2910702。所有数据应用SSPS13.0软件包处理。结果①哈迪温伯格平衡(Hardy-Weinberg s equilibrium)结果显示,GDNF基因rs2910702在病例组中偏离哈迪温伯格平衡(χ2=24.983,P=0.000);②GDNF等位基因频率在病例组与对照组中的分布无统计学差异(P>0.05),但基因型频率分布有统计学差异(P<0.05);③GDNF各基因型与精神分裂症的临床分型、PANSS量表各因子分无明显相关性。结论 rs2973050基因型C/C、rs2910702基因型G/G可能与精神分裂症的发生有关,为精神分裂症的危险基因型。Objective To explore the correlation between gene polymorphisms of glial cell line-derived neurotrophic factor（GDNF） and clinical characteristics of schizophrenia.Methods Altogether 303 schizophrenia patients and 300 healthy controls recruited were consistent with the inclusion and exclusion criteria.Their clinical data and blood samples were collected.The gene polymorphisms of GDNF were determined with PCR-RFLP technique.We selected 2 SNP loci of GDNF gene,rs2973050 and rs2910702.SPSS13.0 software was used to make statistical analysis.Results ① Rs2910702 of GDNF in the patient group was deviated from Hardy-Weinberg’s equilibrium（χ2=24.983,P=0.000）.② The allele frequency of GDNF had no significant difference in distribution between the patient group and the control group（P〉0.05）,but the genotype frequency differed significantly in distribution between the cases and controls（P〈0.05）.③ GDNF genotypes were not significantly correlated with the clinical typing of schizophrenia or factors in PANSS scale.Conclusion Rs2973050 genotype C/C and rs2910702 genotype G/G may be related to the occurrence of schizophrenia;therefore,they are the risk genotypes of schizophrenia

关 键 词：精神分裂症 胶质细胞源性神经营养因子 基因多态性 关联分析 GDNF基因 哈迪温伯格平衡 PANSS量表 

分 类 号：R749[医药卫生—神经病学与精神病学]