胸腺瘤组织中的肿瘤相关巨噬细胞数与其分级、浸润以及患者预后密切相关  

The relation between tumor associated macrophages and the classification,invasion and prognosis in thymoma

作　　者：肖永春[1] 王璐[1] 张玮[2] 姚莉[2] 范林妮[1] 朱瑾[1] 刘一雄[1] 黄高昇[1] 

机构地区：[1]第四军医大学西京医院病理科,陕西西安710032 [2]第四军医大学唐都医院病理科,陕西西安710038

出　　处：《现代肿瘤医学》2011年第6期1045-1049,共5页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:30870947)

摘　　要：目的:检测胸腺瘤组织中肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs)细胞数,探讨TAMs与胸腺瘤临床病理特征的联系,为胸腺瘤的病理诊断及预后评估提供简易可行的新指标。方法:采用免疫组织化学法(SP法)检测95例胸腺瘤组织中的TAMs,电话随访及医院病历记录收集随访资料。单因素检验分析TAMs与胸腺瘤多种临床病理特征的联系,Kaplan-Meier生存曲线分析患者的生存状况。结果:TAMs在不同亚型胸腺瘤中的细胞数明显不同,在B1、B2、B3、C型肿瘤组织中随肿瘤恶性度增加而阳性率逐渐增高,其百分率分别为2.9%、5.4%、11.9%、13.2%(P<0.05),在侵袭性胸腺瘤中的阳性率也明显高于非侵袭性胸腺瘤(P<0.05);单因素分析表明TAMs表达、胸腺瘤分型、侵袭性与胸腺瘤患者术后远期生存率有显著相关性。结论:胸腺瘤组织中TAMs细胞数与其病理分型及侵袭性密切相关,检测TAMs可为判断胸腺瘤患者的预后提供简单易行的客观依据。Objective：To discuss the relation between tumor associated macrophages（TAMs） and its clinicopathological characteristics by counting TAMs in thymoma,and to provide a potential new indicator for the pathological diagnosis and evaluation.Methods： Immunohistochemistry was used to detect TAMs in 95 examples of thymus lymphoma tissues.The prognosis of patients was followed up.Statistical test was employed to analyze the relation of TAMs cells and the clinicopathological characteristics.In addition,the patients survival was analyzed by Kaplan-Meier method.Results： The percentage of TAMs cells varied in different substype B1,B2,B3,C of thymoma,with 2.9%,5.4%,11.9% and 13.2 % respectively（P0.05）,and the positive rate was gradually increased with the prograssion of malignacy degree.The positive rate in invasion thymoma was significantly higher than that in other type of thymoma（P0.05）.For survival analysis,the expression of TAMs,subtype as well as the invision were posotively corelated with the prognosis of thymoma patients.Conclusion： TAMs cells are closely related with pathological type and invasion,and could provide an objective marker for prognosis of thymoma patients.

关 键 词：胸腺瘤 侵袭性 预后 肿瘤相关巨噬细胞 

分 类 号：R730.2[医药卫生—肿瘤] R736.3[医药卫生—临床医学]