人非小细胞肺癌CD46分子的表达及临床意义研究  

Expression and signifiance of CD46 in non-small cell lung cancer(NSCLC)

作　　者：王仕忠[1] 王勇 关乃富[1] 鲍永仪[1] 倪诚[1] 夏蕾[1] 马玲娣[1] 

机构地区：[1]南京医科大学附属常州第二人民医院,江苏常州213003

出　　处：《现代肿瘤医学》2011年第6期1117-1120,共4页Journal of Modern Oncology

基　　金：江苏省社会发展基金资助项目(项目编号:BS2007025);常州市社会发展基金资助项目(项目编号:CS2007216)

摘　　要：目的:研究人非小细胞肺癌组织中CD46的表达水平及意义。方法:免疫组织化学检测人非小细胞肺癌组织中CD46的表达水平,分析其与肿瘤发生发展的相关性。结果:检测66例非小细胞肺癌组织样本,24例鳞癌中14例CD46表达阳性(71.4%),42例腺癌中37例CD46表达阳性(88.1%);66例标本中40例TNM早期患者有32例CD46表达阳性(80.0%),26例TNM中晚期患者有19例CD46表达阳性(73.8%);此外,20例正常肺支气管上皮细胞CD46表达均为阳性,19例正常肺泡上皮细胞CD46表达均为阴性。结论:CD46表达与非小细胞肺癌的病理组织类型及肿瘤细胞的起源有关,与肺癌的TNM分期无关。Objective：To explore the expression level and the meaning of CD46 in non-small cell lung cancer（NSCLC） cells.Methods： All patients with non-small cell lung cancer were examined with immunohistochemisty to measure the expression level of CD46 and analysis the correlation with tumorigenesis.Results： A total of 66 patients with non-small cell lung cancer included squamous carcinoma and adencarcinoma.In 24 squamous carcinoma,patients,14（71.4%） showed positive CD46.In 42 adencarcinoma,patients,37（88.1%） showed positive.40 early stage in TNM,32（80.0%） showed positive in CD46,26 metaphase and telophase stage in TNM,19（73.8%） showed positive.All of the 20 normal lung bronchiolar epithelium samples were positive in CD46,but all of the 19 normal alveolar epithelial samples were negative.Conclusion： The expression of CD46 was related to histlogical type and origin of the tumor cells rather than TNM stage in NSCLC.

关 键 词：非小细胞肺癌 CD46 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]