XRCC1 Arg194Trp多态性与亚洲人群肺癌易感性的Meta分析  

XRCC1 Arg194Trp polymorphism and lung cancer risk in Asian populations: A meta-analysis

作　　者：许崇安[1] 刘佳丽[1] 王晓杰[1] 李琳[1] 冯丹[1] 刘艳[1] 

机构地区：[1]中国医科大学附属第四医院肿瘤内科,辽宁沈阳110032

出　　处：《现代肿瘤医学》2011年第6期1123-1128,共6页Journal of Modern Oncology

摘　　要：目的:应用Meta分析方法评价XRCC1 Arg194Trp基因多态性与亚洲人群肺癌易感性的关系。方法:计算机检索Pubmed、Embase、Cochrane图书馆、万方、CNKI、维普和CBM数据库,全面收集有关XRCC1Arg194Trp基因多态性与亚洲人群肺癌易感性的相关研究。结果:根据入组标准,共13个病例对照研究纳入本系统评价,共计5585例研究对象,其中包括2629例肺癌患者和2956例健康正常人。Meta分析结果表明:XRCC1 194Arg等位基因(ORArg=1.01,95%CI=0.90-1.14,P=0.84)、194Trp携带者(ORArg/Trp+Trp/Trp=1.04,95%CI=0.93-1.15,P=0.50)及194Arg携带者(ORArg/Arg+Arg/Trp=1.14,95%CI=0.94-1.37,P=0.18)均与亚洲人群肺癌易感性无明显统计学关联。结论:虽然194Trp等位基因及其携带者可能导致XRCC1修复DNA损伤能力的降低,但XRCC1 Arg194Trp多态性与亚洲人群肺癌易感性并无明确统计学关联。Objective： To investigate the association between XRCC1 Arg194Trp polymorphism and susceptibility to lung cancer in Asian populations by conducting a meta-analysis.Methods： Publications addressing the association between XRCC1 Arg194Trp polymorphism and susceptibility to lung cancer in Asian populations were selected from Pubmed,Embase,Cochrane library,Wanfang,CNKI,VIP and CBM databases.Results： According to inclusion criteria,thirteen case-control studies were retrieved with a total of 2629 lung cancer patients and 2956 healthy controls.Meta-analysis results showed no association between XRCC1 194Arg allele（ORArg/Trp＋Trp/Trp=1.04,95%CI=0.93-1.15,P=0.50）,194Trp carriers（ORArg/Trp＋Trp/Trp=1.04,95%CI=0.93-1.15,P=0.50） and 194Arg carriers（ORArg/Arg＋Arg/Trp=1.14,95%CI=0.94-1.37,P=0.18） with susceptibility to lung cancer in Asian populations.Conclusion： Although XRCC1 194Trp allele or carriers may lead to reduce capacity of DNA damage repair,XRCC1 Arg194Trp polymorphism showed no obvious association with susceptibility to lung cancer in Asian populations.

关 键 词：肺癌 X线修复交叉互补基因1 多态性 META分析 

分 类 号：R734.2[医药卫生—肿瘤]