局限期小细胞肺癌三维适形超分割放疗及同步化疗的临床研究  

Clinical outcomes of concurrent accelerated fractionation plus three-dimension conformal radiotherapy and chemotherapy for limited-stage small cell lung cancer

作　　者：周绍兵[1] 刘阳晨[1] 高飞[1] 

机构地区：[1]江苏省泰兴市人民医院放疗科,江苏泰兴225400

出　　处：《现代肿瘤医学》2011年第6期1144-1146,共3页Journal of Modern Oncology

摘　　要：目的:观察三维适形超分割放疗及同步化疗治疗局限期小细胞肺癌(LSCLC)的疗效及不良反应。方法:50例LSCLC患者随机分为同步化疗及三维适形超分割放疗DT54Gy组(治疗组)和三维适形超分割放疗DT45Gy组(对照组)。化疗采用EP方案化疗:足叶乙甙(VP-16)100mg/m2,第1-5天;顺铂(DDP)40mg/m2,第1-3天化疗一周期,再同步放化疗,然后继续化疗,共4-6周期。放疗采用三维适形超分割放疗,1.5Gy次/,2次/d,间隔≥6h,5d周/。治疗组肿瘤量DT54Gy,对照组DT45Gy。结果:治疗组与对照组的近期有效率(CR+PR)分别为92.0%和84.0%。1、2、3年生存率分别为80.0%、40.0%、24.0%和76.0%、32.0%、16.0%(P>0.05)。中位生存期分别为24.6和22.3个月。1+2级放射性食管炎、肺炎、骨髓抑制发生率相似。结论:3DCRT超分割放疗及同步化疗在总剂量为54Gy组可获得满意的近、远期疗效,不良反应稍高但可以耐受。Objective： To evaluate the effect of EP regimen delivered concurrently with accelerated fractionation plus three-dimension conformal radiotherapy（3DCRT）for locally small cell lung cancer（LSCLC）.Methods： Fifty patients with LSCLC were randomized into two groups： 25 patients received chemotherapy and accelerated fractionation plus three-dimension conformal radiotherapy DT 54Gy（treatment group）,25 patients received chemotherapy and accelerated fractionation plus three-dimension conformal radiotherapy DT 45Gy（control group）.Chemotherapy ragimen EP（VP-16＋DDP）.In both groups,patients received one cycle chemotherapy,followed by concurrent chemoradiotherapy and then received consolidate chemotherapy.Chemotherapy was used for four to six cycles of EP regimen.Radiotherapy ragimen accelerated fractionation plus three-dimension conformal radiotherapy.1.5Gy per fraction,twice daily.The total dose in treatment group and control group was 54Gy and 45Gy.Results： The overall response rate was 92.0% in treatment group,while 84.0% in control group;The 1,2 and 3 year survival rate in treatment group and control group were 80.0%,40.0%,24.0% and 76.0%,32.0%,16.0%（P0.05）.The median survival time was 24.6 and 22.3 months.There was no difference in grade 1＋2 acute radiation esophagitis,pneumonitis and myelo-suppression between the two groups.Conclusion： The accelerated fractionation plus three-dimension conformal radiotherapy（DT 54Gy） and chemotherapy can achieve satisfactory short-term and long-term outcomes in patients with LSCLS and tolerable to toxicities.

关 键 词：小细胞肺癌 化学疗法 超分割放射治疗 三维适形放射治疗 

分 类 号：R734.2[医药卫生—肿瘤]