钛铸件复合氮化处理的生物安全性研究  

The biological safety of the coating on cast pure titanium treated by compound nitriding

作　　者：王菁[1] 郭天文[1] 李星星[1] 佟宇[1] 

机构地区：[1]第四军医大学口腔医学院修复科,西安710032

出　　处：《实用口腔医学杂志》2011年第3期298-301,共4页Journal of Practical Stomatology

基　　金：国家自然科学基金资助(编号:30171022);陕西省薄膜技术与光学检测重点实验室基金(编号:ZSKJ200906)

摘　　要：目的:评价纯钛铸件表面等离子渗氮、脉冲电弧离子镀膜复合处理后的生物安全性。方法:按照国际ISO 10993标准,选择细胞毒性试验、溶血试验、急性全身毒性试验及口腔黏膜刺激试验,记录实验结果并作统计学分析。结果:钛铸件经渗氮、镀膜复合处理后细胞毒性测试为0级或I级;溶血率为0.45%,有良好的血液相容性;无急性全身毒性反应;口腔黏膜刺激试验阴性,各项指标均符合ISO 10993标准。结论:钛铸件复合氮化处理后无潜在生物学毒性。Objective： To evaluate the biological safety of the coating on cast pure titanium treated by compound nitriding（CN）. Methods ： Samples of cast pure titanium with coating of CN were prepared. Cytotoxicity test, hemolytic test, acute systemic toxicity test and oral mucosa irritation test were carried out according to international standard ISO10993. Results： Cytotoxicity test showed that the samples with CN had no cytotoxicity. The result of hemolytic test indicated that CN samples had a good hemocompatibility and the hemolytic rate was 0.45%. In addition, CN samples had no acute systemic toxicity and no mucous membrane irritation in oral mucous. Conclusion： The new coating on cast pure titanium by compound nitriding has good biological safety.

关 键 词：钛铸件 等离子渗氮 脉冲电弧离子镀 生物安全性 

分 类 号：R783.1[医药卫生—口腔医学]