混合真菌多糖制剂对小鼠耐力及免疫功能的影响  

Effect of a Mixed Fungi Polysaccharides Granules on the Endurance Capacity and Immunity of Mice

作　　者：刘立[1] 田刚[1] 迟国兴[1] 睢大筼[2] 于晓凤[2] 

机构地区：[1]白求恩医科大学制药厂,长春130021 [2]白求恩医科大学药理教研室

出　　处：《中国生化药物杂志》1999年第4期191-193,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：研究混合真菌多糖制剂对小鼠耐力及免疫功能的影响。方法：混合真菌多糖制剂按４．０、８．０ｇ／ｋｇ连续灌胃给药 ７ ｄ，分别测定小鼠耐缺氧能力、抗疲劳作用、免疫器官称重以及网状内皮系统吞噬功能等。结果：混合真菌多数能明显提高小鼠的耐缺氧及抗疲劳能力，促进正常小鼠免疫器官重量增加，增加网状内皮系统的吞噬功能，并能使环磷酸胺所致免疫功能低下小鼠外周血白细胞增加，促进骨髓有核细胞增殖及增加脾指数。结论：混合真菌多精制剂具有增强机体免疫功能及升高白细胞等作用。Purpose: To research the mixed fungi polysaccharides granules, made of the deep fermentation of changbaishan-wild grawing hedgehog hydnum, tremmella and glossy ganodema which influenced mice tolerance and immune function. Methods: The mixed fungi polysaccharides granules were administered (ig) at the doses of 4. 0 and 8. 0 g/kg for seven days, we respectively determined theability to tolerate hypoxia and fatigue, the weights of immune organ and the phagocytosis of reticuloendothelium in normal mice. Results: It could significally raise the ability to tolerate hypoxia and fatigue, increase the weights of immune organ and enhance the phagocytosis of reticuloendothelium in normal mice, it could also increase the number of peripheral blood leukocytes and the spleen index and promote marrow nuclear cell proliferation in immunosuppressive mice by cyclophosphamide. Conclusion: The mixed fungi polysaccharides granules have the effects to enhance immune function and raise leukocytes in organism.

关 键 词：真菌多糖 耐缺氧 抗疲劳 免疫功能 小鼠 

分 类 号：R977.6[医药卫生—药品]