经肝动脉区域性化疗联合短时血液滤过治疗结肠癌术后肝多发转移  

Hepatic artery regional chemotherapy plus hemofiltration in the treatment of liver multiple metastases after radical resection of colon cancer

作　　者：严俊 王群 朱梅芳 许珲东 梁哲通 

机构地区：[1]上海市市东医院肿瘤外科,上海200438

出　　处：《中国现代医学杂志》2011年第13期1515-1518,共4页China Journal of Modern Medicine

摘　　要：目的探讨结肠癌根治术后肝转移病人经肝区域性化疗联合血液滤过治疗的疗效及药物不良反应,以提高治疗效果和改善预后。方法将58例1998年1月～2008年1月在该院手术并于术后出现肝转移的病人,分组进行FAM方案肝脏区域性化疗联合血液滤过治疗和单纯静脉化疗,用每次化疗后CT或MRI复查对比判别疗效,分析转移瘤累计直径变化及1～3年生存率和化疗药物不良反应总数。同期普通静脉化疗设为对照组。结果肝脏区域性化疗联合血液滤过治疗组的转移瘤累计直径变化比普通静脉化疗有显著的差别,1～3年生存率明显提高,同时药物不良反应明显减少。结论经肝动脉区域性化疗联合短时血液滤过治疗结肠癌术后肝转移效果优于静脉化疗,不良反应明显减少。【Objective】 To investigate curative effects and drug adverse reaction of hepatic artery regional chemotherapy plus hemofiltration for the treatment of liver multiple metastases after radical resection of colon cancer,improved therapeutic effect and prognosis for the patient.【Methods】 58 patients who were suffered from liver multiple metastases of post-operative colon cancer in our hospital from 1998.1 to 2008.1,were divided randomly into hepatic artery regional chemotherapy plus hemofiltration group and simple venous chemotherapy group with FAM regimens.Accumulative diameter variation of hepatic metastatic tumors by using CT or MRI and drug adverse reaction were observed,survival rates of 1-year,2-years,3-years were calculated.【Results】 Accumulative diameter variation of hepatic artery regional chemotherapy plus hemofiltration group have significant difference compared with control group,survival rate improved and drug adverse reaction decreased significantly.【Conclusions】 Hepatic artery regional chemotherapy plus hemofiltration is more effective than simply venous chemotherapy in the treatment of liver multiple metastases after radical resection of colon cancer,and drug adverse reaction decreased significantly.

关 键 词：结肠癌 肝转移 化疗 血液滤过 

分 类 号：R735.35[医药卫生—肿瘤]