中性粘多糖对沙土鼠脑缺血再灌注红细胞膜的保护作用  

Protective effect of neutral mucopolysaccharide on RBC membrane during ischemia reperfusion brain damage in gerbil

作　　者：丁素菊[1] 郑惠民[1] 张仁琴[1] 侯晓军[1] 邓本强[1] 

机构地区：[1]第二军医大学长海医院神经内科,上海200433

出　　处：《第二军医大学学报》1999年第9期627-629,共3页Academic Journal of Second Military Medical University

基　　金：上海市自然科学基金

摘　　要：目的：探讨中性粘多糖（ Ｎ Ｍ ）对沙土鼠缺血再灌注后红细胞膜的保护作用。方法：采用沙土鼠脑缺血再灌注模型，观察 Ｎ Ｍ 对红细胞免疫粘附功能的影响，检测红细胞超氧化物歧化酶（ Ｒ Ｂ Ｃ Ｓ Ｏ Ｄ）和脂质过氧化物代谢产物丙二醛（ Ｒ Ｂ Ｃ Ｍ Ｄ Ａ）的含量，同时与淀粉对照组进行比较。结果： Ｎ Ｍ 可使沙土鼠再灌注时 Ｒ Ｂ Ｃ免疫粘附功能得到恢复； Ｒ Ｂ Ｃ Ｓ Ｏ Ｄ的含量轻度提高； Ｒ Ｂ Ｃ Ｍ Ｄ Ａ 含量明显降低。结论： Ｎ Ｍ 通过抗氧化作用对 Ｒ Ｂ Ｃ免疫粘附功能有调节作用，从而对沙土鼠缺血再灌注脑组织损伤时红细胞膜起到保护作用。Objective: To study the protective effect of neutral mucopolysaccharide (NM) on RBC membrane during ischemia reperfusion brain damage in gerbil. Methods: The functional changes of red blood cell immune adherence (RCIA) and the content of red blood cell superoxidate dismustase (RBC SOD), red blood cell malonialdehyde (RBC MDA) were observed by means of cerebral ischemia reperfusion in gerbil. Results: NM recovered the function of RCIA; increased RBC SOD; decreased RBC MDA. Conclusion: NM regulates the function of RCIA by antioxygenic effection, and has the protective effect on RBC membrane during ischemia reperfusion brain damage.

关 键 词：中性粘多糖 红细胞 脑缺血 再灌注损伤 沙土鼠 

分 类 号：R743.31[医药卫生—神经病学与精神病学]