Taurolidine抗肿瘤应用的研究进展  

RESEARCH PROGRESS ON ANTICANCER EFFECT OF TAUROLIDINE

作　　者：江涛[1] 于少卿[1] 薛学温[2] 

机构地区：[1]中国海洋大学医药学院,教育部海洋药物重点实验室,山东青岛266003 [2]青岛大学医学院附属医院,山东青岛266003

出　　处：《海洋湖沼通报》2011年第2期115-119,共5页Transactions of Oceanology and Limnology

摘　　要：滔罗定(Taurolidine)是1种广谱抗菌药,临床上可用于多种感染疾病的治疗。近年来大量研究表明Taurolidine具有良好的抗肿瘤活性。Taurolidine的抗肿瘤机制尚未完全明确,已有的研究证明其通过促进细胞凋亡、抑制血管生成、减少肿瘤黏附、下调促炎细胞因子释放水平和刺激外科手术后抗肿瘤免疫调节等多种途径发挥抗肿瘤作用。本文综述Taurolidine在抗肿瘤方面的研究进展。Taurolidine is a broad-spectrum antibiotic and has been used to treat infectious diseases in clinics. In recent years, it is reported that Taurolidine has the anticancer activities. Although the mechanism has not completely known, the present research results show that Taurolidine＇s anti-tumor effects may be achieved by enhancing apoptosis, inhibiting anglogenesis and tumor adherence, down-regulating pro-inflammatory cytokine levels, and stimulating the immune system in response to surgically.

关 键 词：TAUROLIDINE 抗肿瘤 综述 

分 类 号：R979.9[医药卫生—药品]