鼻咽癌组织中微血管计数及其临床意义  

Microvascular count in nasopharyngeal carcinoma and its clinical significance

作　　者：袁莲香 何伟民 张斌 唐文瑜 

机构地区：[1]柳州市肿瘤医院病理科,545005

出　　处：《诊断病理学杂志》1999年第3期163-165,共3页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨鼻咽癌（ＮＰＣ）肿瘤中微血管计数（ＭＶＣ）与其生物学行为的关系。方法应用免疫组织化学ＬＳＡＢ法，对１０５例具有完整临床资料的鼻咽癌组织及１５例鼻咽部粘膜慢性炎症的石蜡块进行血管内皮细胞ＣＤ３４标记；在病理彩色图文分析系统（ＣＩＡＳ），免疫组织化学专项分析中进行血管计数统计。结果１５例鼻粘膜慢性炎症组织中ＭＶＣ为２３．４３±４．１８，１０５例ＮＰＣ组织中ＭＶＣ为４２．６９±１１．５１，鼻咽癌ＭＶＣ较慢性炎症对照组明显升高，且具有显著性差异（Ｐ＜０．００１）；１０５例ＮＰＣ病例中颈淋巴结转移６７例，ＭＶＣ为４６．３２±１０．７４，无淋巴结转移３８例，ＭＶＣ为３６．２９±１０．０２，两组之间有显著性差异（Ｐ＜０．０１）；但１０５例ＮＰＣ病例中组织学分型间的ＭＶＣ没有显著性差异。结论提示ＭＶＣ可作为预测鼻咽癌早期颈淋巴结转移的一个指标。Objective To study the relationship between biological behavior and microvascular count (MVC) in neoplasticcancer. Methods In 105 cases with nasopharyngeal carcinoma (NPC) and 15 cases with nasopharyngeal chronic inflammation,the vascular endothelial cells were marked with CD34 by LSAB immunohistochemical method and microvascular vessels were count- ed by computer-assisted immunohistochemical analysis (CIAS). Results The mean MVC in 15 cases of nasal mucous mem-brane chronic inflammation was 23.43±4.18, and in 105 cases of NPC tissues was 42.69± 11.51 (P < 0.01). Of the 105NPC cases, there were 67 cases with metastasis and 38 cases without; the MVCs were 46.32 ± 10.74 and 36.29± 10.02 respec-tively (P < 0.01). However, in the 105 NPC cases, there were no significant differences in MVC among various histological pat- terns. Conclusion MVC is a predictive sign of lymph node metastasis.

关 键 词：鼻咽癌 微血管密度 CD34 MVC 

分 类 号：R739.630.2[医药卫生—肿瘤]