生物催化在农药合成中的应用  

The Application of Biocatalysis in the Synthesis of Pesticides

作　　者：刘卫德[1] 蒋细良[1] 范亮波[1] 冀颖[1] 牛静[1] 李梅[1] 

机构地区：[1]中国农业科学院植物保护研究所农业部生物防治重点开放实验室,北京100081

出　　处：《农药》2011年第6期391-394,403,共5页Agrochemicals

基　　金：植物病虫害生物学国家重点实验室开放课题(2006PD5)

摘　　要：对现有农药进行结构修饰及制备光学纯的手性农药是当前农药研究开发的重要内容,其中常涉及很多高选择性反应步骤,采用传统化学方法往往操作复杂、成本高并可能造成环境污染。生物催化具有反应条件温和、高效、高选择性及低污染等优点,成为化学催化的重要补充。近年来,生物催化在农药合成中的应用日益受到关注。介绍了生物催化在农药分子的选择性结构修饰及手性农药去消旋化等方面的研究及应用情况。Structural modification of existing pesticides and preparation of optically pure chiral pesticides are important part of current pesticides research and development,which often involves many highly selective steps,while the traditional way has the defects of complicated process,high cost as well as environmental pollution problems.Biocatalysis has been a viable alternative to chemical catalysis due to the propensity to operate at moderate conditions,high selectivity and catalytic efficiency,as well as low environmental pollution.Particularly,the application of biocatalysts to the synthesis of pesticide has grown rapidly in recent years.The research and application of biocatalysis to the selectively structural modification of pesticide and deracemization of chiral pesticide was introduced.

关 键 词：生物催化 农药 结构修饰 外消旋体拆分 不对称合成 

分 类 号：TQ450.6[化学工程—农药化工]