鼻咽癌在全身骨显像鼻部感兴趣区放射性异常的分析  

Study on nasal radioactive anomalies of nasopharyngeal carcinoma in bone imaging

作　　者：王渊恺[1] 袁杰[1] 张光明[1] 刘从进[1] 陆云[1] 张锦明[1] 朱汇庆[1] 刘兴党[1] 

机构地区：[1]复旦大学附属华山医院核医学科,上海200040

出　　处：《国际放射医学核医学杂志》2011年第1期20-23,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：目的研究全身骨显像中各类患者鼻部ROI放射性异常。方法对712例临床诊断为鼻咽癌或疑似鼻咽癌的患者和1036例其他受检者用^99Tc^m-亚甲基二膦酸行全身骨显像，勾画其鼻部ROI，并分为6组（A～F组），对ROI每像素放射性计数最大值、ROI每像素放射性计数平均值、ROI每像素放射性计数平均值与本底对照区每像素放射性计数平均值的比值做统计学分析。结果A组ROI每像素放射性计数平均值比F组低（t=3．47，P〈0．01），B、C、E=i组比F组高（tA=17．73，tB=4．39，tE=2．85，P均〈0．01）。B、C两组ROI每像素放射性计数平均值与本底对照区平均值的比值显著高于F组（t=24．99，t=13．11，P均〈0．01）。结论临床怀疑或确诊为鼻咽癌或有其他鼻部肿瘤病史的检查者、有明确良恶性肿瘤病史的检查者，较一般检查者鼻部放射性明显增高。通过分析鼻部ROI数据可更早、更准确发现骨显像中鼻部的异常。Objective To investigate radioactive abnormalities of nasopharyngeal carcinoma （NPC） in the bone imaging. Methods Divide 712 diagnosed or suspected NPC patients and other 1036 patients in ^99Tc^m- methylene diphosphonate bone imaging into 6 groups. Draw ROI of nasal region, and then analysis radioactive counts of ROI. Results Average radioactivity counts of A group were lower than F group （t=3.47, P〈0.01 ）, and B, C and E groups higher than F group. It showed a significantly statistical difference （tA= 17.73, tB= 4.39, tE= 2.85, P〈0.01）. The ratio of the average radioactivity counts per pixel and the background radioactivity counts of B and C groups were significantly higher than F group （t= 24.99, t= 13.11, P〈0.01）. Conclusion Radioactive counts of nasal part in diagnosed orsuspected NPC and other carcinoma of nasal patients and the patients with the history of benign or malignant carcinoma increased significantly.

关 键 词：鼻咽肿瘤 99M锝美罗酸盐 全身成像 

分 类 号：R739.63[医药卫生—肿瘤] R817.4[医药卫生—临床医学]