国产吉西他滨联合顺铂治疗48例晚期乳腺癌临床观察  

Clinical observation of 48 patients with advanced byeast cancer treated with Gemcitabine combined with Cisplatin

作　　者：陈露[1] 

机构地区：[1]河南省商丘市第一人民医院肿瘤科,河南商丘476100

出　　处：《中国医药导报》2011年第17期70-71,共2页China Medical Herald

摘　　要：目的：国产吉西他滨联合顺铂治疗晚期乳腺癌的疗效及不良反应。方法：48例晚期乳腺癌患者采用吉西他滨1 000 mg/m2,静脉滴注30 min,第1天,第8天;顺铂2540 mg/m2,第24天。21 d为1个周期,治疗2个周期后评价疗效及不良反应。结果：48例均可评价疗效,完成周期数共205个。完全缓解（CR）4例,部分缓解（PR）18例,稳定（SD）16例,进展（PD）10例,总有效率（CR＋PR）为45.8%,临床获益率（CR＋PR＋SD）为79.1%,中位疾病进展时间8.5个月,中位生存期为12.1个月（2.251.5个月）。主要不良反应为骨髓抑制、胃肠道反应。结论：国产吉西他滨联合顺铂治疗晚期乳腺癌疗效好,毒副反应轻微,耐受性好,是晚期乳腺癌的有效治疗方案。Objective： To study the efficacy and toxi effects of Gemcitabine combined with Cisplatin in treating patients with advanced breast cancer.Methods： 48 patients with advanced breast cancer were treated with Gemcitabine 1 000 mg/m2 on day1 and day8,cisplatin 25-40 mg/m2 on days 2-4.The chemotherapy repeated every 3 weeks.Efficacy and toxic reactions were reviewed after 2 cycles of chemotherapy.Results： 48 patients were evaluable for response： CR 4 cases,PR 18 cases,SD 16 cases and PD 10 cases.The overall response rate（ORR） was 45.8% and the disease control rate（DCR） was 79.1%.The median time to progression（TTP） was 8.5 months,and median survival time（OS） was 12.1 months.The main toxic reactions included myelosuppression,gastrointestinal toxic reactions.Conclusion： Gemcitabine combined with Cisplatin is deeective in the treatment of patients with advanced breast cancer,the toxic reaction is acceptable.It may be an effective regimen.

关 键 词：吉西他滨 顺铂 乳腺肿瘤 化学疗法 

分 类 号：R737.9[医药卫生—肿瘤]