5-羟色胺_7 受体介导刺激中缝背核对视交叉上核光敏神经元单位放电的抑制效应  

5 HT_7 RECEPTOR MEDICATES THE INHIBITORY EFFECT OF DORSAL RAPHE NUCLEUS STIMULATION ON UNIT DISCHARES OF LIGHT SENSITIVE NEURONS OF SUPRACHIASMATIC NUCLEUS

作　　者：蒋星红[1] 魏晓萍[1] 张惠琴[1] 刘运林[1] 俞光第[1] 印其章[1] 

机构地区：[1]苏州医学院神经生物学研究室,苏州215007

出　　处：《中国神经科学杂志》1999年第3期194-198,共5页

基　　金：国家自然科学基金

摘　　要：观察刺激中缝背核（ＤＲ）对大鼠视交叉上核（ＳＣＮ）光敏神经元单位放电的影响，并进行药理学分析。结果表明：刺激ＤＲ能明显抑制ＳＣＮ神经元光诱发放电。这种抑制作用能被５ＨＴ２／７受体拮抗剂ｒｉｔａｎｓｅｒｉｎ 阻断，但不能被选择性５ＨＴ２ 受体拮抗剂１ＮＰ阻断。对５ＨＴ７ 有较高亲和力的神经阻断剂ｃｌｏｚａｐｉｎｅ也能阻断刺激ＤＲ的抑制效应。实验结果提示，刺激ＤＲ对ＳＣＮ 光敏神经元放电的抑制，可能是通过５ＨＴ７The effect of dorsal raphe nucleus (DR) stimulation on the unit discharge of suprachiasmatic nucleus (SCN)neurons was studied and analyzed pharmacologically in the Wistar rats.Experimental results showed that DR stimulation could significantly inhibit the light induced discharge of SCN neurons.This inhibitory effect of DR stimulation on the discharge of light sensitive SCN neurons was blocked by ritanserin(5 HT 2/7 antagonist) but not by 1 NP (5 HT 2 selective antagonist). Neuroleptic clozapine which has a moderate affinity to 5 HT 7 receptor could also block the inhibitory effect of DR stimulation. It was suggested that the inhibitory effect of DR stimulation on the light induced discharges of SCN neuron might be mediated by 5 HT 7 like receptor.

关 键 词：视交叉上核 中缝背核 光敏神经元 5-HT 

分 类 号：R338[医药卫生—人体生理学]