豚鼠听通路核团内诱发电位频谱分析  

Spectral Analysis of AEP From the Nuclei of Auditory Pathway in Guinea Pigs

作　　者：刘邦德[1] 陈丽[1] 吴展元[2] 

机构地区：[1]咸宁医学院附属第一医院耳鼻喉科,咸宁437100 [2]湖北医科大学附属第一医院耳鼻喉科,武汉430060

出　　处：《咸宁医学院学报》1999年第3期152-155,共4页Journal of Xianning Medical College

摘　　要：目的：探讨听觉脑干反应频域参数合成机理。方法：用计算机叠加技术和脑干核团定位技术，分别测试听觉脑干反应（ＡＢＲ） 、耳蜗核腹核听觉诱发反应（ＣＮ－ ＡＥＰ） 、内上橄榄核团内听觉诱发反应（ ＭＳＯ－ ＡＥＰ） 、外侧丘系腹核内听觉诱发反应（ＬＬ－ ＡＥＰ） 和下丘核中央核团内听觉诱发反应（ＩＣ－ ＡＥＰ） 。采用平均功率谱分析方法，对ＡＢＲ及ＡＥＰ的主波单波进行谱分析。结果：豚鼠ＡＢＲ 呈现波Ⅰ、Ⅱ、Ⅲ、Ⅳ四个波，ＣＮ－ ＡＥＰ 中波Ⅱ为主波，ＭＳＯ－ ＡＥＰ波Ⅲ为主波，ＬＬ－ＡＥＰ波Ⅳ为主波，ＩＣ－ ＡＥＰ波Ⅴ为主波，ＡＥＰ中各主波与ＡＢＲ 相对应波潜伏期无显著性差异（Ｐ＞ ０ ．０５） 。与ＡＢＲ 频谱相比，ＡＥＰ各主波单波频谱均存在三个谱能量集中区，即Ｆ０ 、Ｆ１ 和Ｆ２ ，但三谱峰值有不同程度下降，低位脑干以Ｆ２ 下降明显（Ｐ＜ ０ ．０１） ，高位脑干以Ｆ１ 下降明显（Ｐ＜ ０ ．０１） ；各谱峰中心频率向低频移动，频谱带宽变窄。结论：整个听通路各核团均不同程度含有Ｆ１ 和Ｆ２ 固有振荡频率成份。低位脑干以Ｆ２ 合成贡献为主，高位脑干以Ｆ１ 合成贡献为主，Ｆ１ 和Ｆ２ 是多种神经元核团及听神经不同谐振频率所合成。Objective To investigate the compositional mechanism of parametric configuration of auditory brain stem response in the frequency domain.Methods Auditory brain stem response (ABR) and the auditory evoked potential of cochlear nucleus (CN-AEP),mediar superior olivary nucleus (MSO-AEP),lemnisci lateralis nucleus (LL-AEP) and inferior colliculus (IC-AEP) were recorded with repetition and average technique of computer and orientational technique for brain stem nucleus.ABR and the main single waves of the AEP of every nueleus were analysed with the frequency spectrum.Results ABR in guinea pigs showed waves Ⅰ,Ⅱ,Ⅲ,and Ⅳ and the wave Ⅱin CN-AEP,wave Ⅲ in MOS AEP,wave Ⅳ in LL AEP,wave Ⅴ in IC AEP was presented as main waves respectively.The incubation period of the main waves in AEP showed no significant difference with that of the corresponding waves in ABR (P>0.05).In contrast with ABR frequency spectra,in the frequency spectra with main single waves of AEP of every nucleus there were three energy peaks:F 0,F 1,F 2,which showed differently decreasing—the main decreasing showed in F 2 of lower brain stem spectrum (P<0.01) and in F 1 of higher brain stem spectrum (P<0.01);the band of spectrwm was narrower than that of ABR,and the major peak energy moving to the lower frequency.Coclusion Every nucleus of auditory pathway includes the resonant frequencies of F 1 and F 2.The lower brain stem nucleus contributes more to F 2 and the higher brain stem nucleus to F 1.Both F 1 and F 2 in ABR may be composed of the different resonant frequencies of nuclei and auditory nerve.

关 键 词：谱分析 核团 听通路 听觉 脑干诱发电位 

分 类 号：R741.044[医药卫生—神经病学与精神病学] R764.04[医药卫生—临床医学]