近交系HFJ大鼠血清中IL-1β、IL-2和IL-10观察研究  

Observation and study on IL-1β,IL-2 and IL-10 in serum of inbred HFJ rats

作　　者：段肖翠[1] 吕占军[1] 蔡月花[1] 王秀芳[1] 侯洁[1] 刘军须[1] 刘福英[1] 谢英[1] 

机构地区：[1]河北医科大学河北省实验动物重点实验室,石家庄050017

出　　处：《医学动物防制》2011年第5期436-437,共2页Journal of Medical Pest Control

基　　金：河北省科技支撑计划重点项目(09276426D)

摘　　要：目的比较观察本实验室培育的近交系HFJ大鼠和Wistar大鼠血清中IL-1β、IL-2和IL-10的含量。方法 HFJ大鼠和远交群Wistar大鼠各10只,应用ELISA法分别检测其血清IL-1β、IL-2和IL-10水平。结果 HFJ大鼠血清中IL-1β、IL-2的含量与Wistar大鼠相比差异无统计学意义(P>0.05),HFJ大鼠血清中IL-10的含量高于Wistar大鼠组,差异有统计学意义(P<0.05)。且HFJ大鼠的IL-1β、IL-2和IL-10总体离散度明显小于Wistar大鼠组。结论 HFJ大鼠血清IL-10高于Wistar大鼠且近交系HFJ大鼠的IL-1β、IL-2和IL-10,测定值较为均一,离散度均低于Wistar大鼠。Objective To comparative study the contents of IL-1β,IL-2 and IL-10 in serum of Wistar rats and high fecundity inbred HFJ rats bred in our lab.Method Selecting 10 cases of HFJ rats and 10 cases of Wistar rats,and using ELISA to detected IL-1β,IL-2 and IL-10 in serum of them.Results There was no difference between Wistar group and HFJ group at the level of IL-1β and IL-2（P0.05）.The level of IL-10 in HFJ group was higher than that in Wistar group（P0.05）.The overall dispersion of IL-1β,IL-2 and IL-10 in HFJ rats group was significantly lower than Wistar rats group.Conclusions IL-10 in HFJ was higher than Wistar rats,and the measured values of IL-1β,IL-2 and IL-10 were more relatively uniform in HFJ,and the dispersion of IL-1β,IL-2 and IL-10 in HFJ rats group was lower than Wistar rats group.

关 键 词：近交系HFJ大鼠 IL-1Β IL-2 IL-10 

分 类 号：R-332[医药卫生]