正交试验法优化叶黄素软胶囊制备处方  

Optimization of Lutein Soft Capsule Preparation by Orthogonal Experiment

作　　者：尹俊涛[1] 鲁萍[2] 闫丽丽[2] 王新春[2] 

机构地区：[1]石河子开发区神内食品有限公司,石河子832000 [2]石河子大学药学院,石河子832002

出　　处：《石河子大学学报（自然科学版）》2011年第2期215-217,共3页Journal of Shihezi University(Natural Science)

基　　金：新疆兵团工业科技攻关项目(2009GG35);科技部科技人员服务企业行动项目(SQ2009GJG4102765)

摘　　要：以药用大豆油为分散介质,蜂蜡为助悬剂,大豆磷脂为润湿剂,以沉降比和再分散性为指标,正交设计优选叶黄素软胶囊内容物的制备处方。结果表明,叶黄素软胶囊内容物的最佳配比为叶黄素-玉米黄素-药用大豆油-蜂蜡-大豆磷脂(14.4∶0.6∶80∶1∶4),制备得到的软胶囊内容物均匀、稳定、流动性好。The preparation of lutein soft capsule was optimized by orthogonal design with evaluation indexes such as sedimentation ratio and redispersibility,by taking soybean oil as the disperse medium,beeswax as the suspending agent,and soybean phospholipid as the moistening agent.The results showed that the optimal proportion of soft capsule contents were made from lutein,zeaxanthin,soybean oil,beeswax and soybean phosphoilpid（14.4∶0.6∶80∶1∶4）and the contents of soft capsule were well-distributed with good stabilization and fluidity.

关 键 词：叶黄素 软胶囊 正交设计 内容物 

分 类 号：R965.2[医药卫生—药理学]