食管癌微血管定量及PCNA表达的临床意义  

The Significance of Microvessel Count and PCNA Expression in Esophageal Cancer

作　　者：仲崇俊[1] 范崇九[1] 陆松华[1] 刘俊[1] 唐有余[1] 于秀 

机构地区：[1]江苏省海安县人民医院,海安226600 [2]南通医学院外科实验室,南通226000

出　　处：《浙江肿瘤》1999年第3期162-163,共2页

摘　　要：[目的］检测食管癌CD34和PCNA的表达，探讨微血管密度和细胞增殖状态与食管癌临床病理的关系。[方法］运用免疫组化法对30例食管癌手术标本进行CD34和PCNA检测。［结果］CD34标记的微血管在食管癌中呈异质性。高分化、早期食管癌微血管密度明显低于低分化、中晚期食管癌（P＜0.05和P＜0.01），同样PCNA标记指数在高分化和早期食管癌中明显较低（P＜0.05和P＜0.01）。存活5年以上与5年以内复发死亡者之间微血管密度和PCNA指数差异有显著性意义（P＜0．01）。［结论］微血管定量和PCNA对食管癌预后判断有重要意义。[Purpose]T0 investigate the relationship between microvessel count, cell proliferation and clinicopathology in esophageal cancer.[Method]Immunohistochemical method was used to detect CD34 and PCNA expression in 30 cases of esophageal cancer. [Results] Microvesselslabelled by CD34 scatter heterologically. MVC in high grade differenciation, eary mp mph- cancer wi significanhy lower than tha in lowgrade differenciation, advanced sop esophageal caner (P <0.05 and P < 0.01 ). Similarly, PCNA LI was lower in high grade differenciation,early stage esophageal cancer(P < 0.05 and P < 0.01 ). MVC and PCNA LI in the patients suboved over 5 years we significantly lower than inthere died within 5 years (P < 0.01 ). [ Conclusion]MVC and PCNA have significance on prognosis in esophageal cancer.

关 键 词：食管肿瘤 CD34 PCNA 免疫组化 微血管定量 

分 类 号：R735.102[医药卫生—肿瘤]