bcl-2与nm-23在胆囊癌发生及发展中的作用  

Effect of bcl-2 and nm-23 in Gallbladder Cancer

作　　者：王贵和[1] 赵铁军[1] 夏飞[1] 桑卫东[1] 

机构地区：[1]安徽省铜陵市人民医院,铜陵244000

出　　处：《浙江肿瘤》1999年第3期164-165,共2页

摘　　要：［目的］探讨抗凋亡基因bel－2和肿瘤转移抑制基因nm－23在原发性胆囊癌发生及发展中的作用。［方法］保用免疫组化方法对38例胆囊癌及30例慢性胆囊炎组织中bcl－2及nm-23对基因蛋白表达进行测定。［结果］胆囊癌中的bcl-2及nm-23的阳性表达分别为60．6％、50．0％，显著高于慢性胆囊炎组织（16．7％、20％，P＜0.01），且bcl-2和nm－23表达与胆囊癌组织分化程度及临床分期密切相关，nm-23表达与淋巴结转移呈负相关。［结论]bcl-2及nm-23对基因在胆囊癌发生及发展中起重要作用，前者过度表达多见于胆囊癌早期．而后者则决定着胆囊癌的浸润及淋巴结转移，是晚期事件。[Purpose]To investigate the effect of bel-2 and nm-23 in gallbladder cancer. [Method]To detect the expression of bel-2 and nm-23 in 38 cases of gallbladder cancer and 30 on of chronic cholecystitis by SP immunchistochemical staining. [Results]The positive rate of bcl-2and nm-23 expression was significantly higher in gallbladder cancer(60. 6%, 50. 0%) than that in chronic cholecystitis (16. 7%, 20% ) (P <0.01). The expression of bel-2 and nm-23 cledy related to cancer cell djfferenhation and clinic stage. nm-23 expression revealed negativecorrelation with lymph nodes metastasis. [Conclusions]bel-2 and nm-23 mey play an important role in the pathogenesis of gallbladder cancer.Overexpression of bcl-2 is common in the early stage of gallbladder caner and nm-23 presents the oncer progress or advanced stage.

关 键 词：胆囊肿瘤 免疫组化 BEL-2 NM-23 

分 类 号：R735.8[医药卫生—肿瘤]