脂肪因子visfatin与缺血性脑血管病相关性及作用机制的研究  

The study on the correlation and mechanism of action of adipokine visfatin and ischemic cerebrovascular disease

作　　者：孔庆霞[1] 夏敏[1] 吴昭英[1] 蔡高梅[1] 李继峰[1] 孙卓祥[2] 胡军利[3] 褚旭[1] 宋进[1] 

机构地区：[1]济宁医学院附属医院神经内科,山东济宁272100 [2]济宁医学院附属医院检验科,山东济宁272100 [3]济宁医学院附属医院超声科,山东济宁272100

出　　处：《中风与神经疾病杂志》2011年第5期411-413,共3页Journal of Apoplexy and Nervous Diseases

基　　金：山东省卫生厅资助课题;面上项目(编号:HZ013)

摘　　要：目的通过检测急性脑梗死患者血清visfatin水平来探讨该因子与脑梗死的相关性及发病的关系。方法分为健康对照组(A组)和实验组(B组),根据测定的颈总动脉内膜中层厚度(IMT),B组又分为无动脉粥样硬化组(B1组)和动脉粥样硬化组(B2组),常规化验空腹血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血糖,用酶联免疫吸附试验(ELISA)法来测定各组血清visfatin水平,分析visfatin与脑梗死的相关性及发病的关系。结果 visfatin水平B组高于A组,B2组高于B1组,logistic回归分析示visfatin含量越高越容易患动脉粥样硬化。结论 visfatin可作为动脉粥样硬化的独立危险因素,高水平血清visfatin与脑梗死的发病相关。Objective To explore the correlation and pathogenesy of visfatin and ischemic cerebrovascular disease by detecting the level of blood serum visfatin.Methods The two group were control group（A group）and experimental group（B group）.B group was divided to B1 group and B2 group according to the metered IMT.TC,TG,HDL-C,LDL-C and blood sugar were commonly examined.ELISA was used to determine the level of blood serum visfatin.The correlation and pathogenesy of visfatin and ischemic cerebrovascular disease were analyzed.Results The level of visfatin of B group was higher than that of A group,and that of B2 group was higher than that of B1 group.Logistic regression analysis showed the higher the content of visfatin,the more liability of atherosclerosis was.Conelusion Visfatin may be the independent risk factor for cerbral infarction,and high level of visfatin has the correlation with the pathogenesy of the disease.

关 键 词：脂肪因子 VISFATIN 动脉粥样硬化 脑梗死 

分 类 号：R743.3[医药卫生—神经病学与精神病学]