慢性甲醇中毒性视神经病变晚期视觉电生理改变  

Optic electraphysiology in later stage of chronic optic neuropathy caused by slow poisoning of methanol

作　　者：张铭连[1] 宁俊恩[1] 周忠友[1] 杨志锐[1] 闫素霞[1] 

机构地区：[1]邢台市眼科医院

出　　处：《中国中医眼科杂志》1999年第3期145-147,共3页China Journal of Chinese Ophthalmology

基　　金：河北省1998年科学技术研究计划项目

摘　　要：目的：观察慢性甲醇中毒性视神经病变晚期视觉电生理改变。方法：对２１例（４２只眼）患者随访２年并进行视觉电生理检测。结果：图形视觉诱发电位表现为Ｐ１００潜伏期延长和Ｐ１００波幅值降低，与正常对照组之间的差异非常显著（Ｐ＜００１），闪光视网膜电图的ａ、ｂ波潜伏期和波幅值与正常对照组比较差异无显著性（Ｐ＞００５）。结论：甲醇中毒的眼部损害部位主要在视神经，中毒早期和晚期的视觉电生理改变基本一致。OBJECTIVE: To observe changes of visual electraphysiology in the patients with chronic optic neuropathy caused by slow poisoning of methanol. METHODS: Of the 21 patients, 42 eyes had mean follow up of 2 years and visual evoked potential ( VEP ) and electroretinogram ( ERG ) were determined. RESULTS: Pattern VEP appeared a delay of incubation of P100 and reduction of amplitude of P100. There was statistic significant between the patients and control group ( P <0 01).The difference of incubation and amplitude of F ERG in a wave and b wave was not statistically significant ( P >0 05). CONCLUSIONS: Damage of optic nerve by methanol toxicity is most severe in the ocular tissues. The change of visual electro physionlogy in both early and later stage appeared obviously not difference.

关 键 词：视神经病变 视觉电生理 甲醇 视觉诱发电位 

分 类 号：R774.6[医药卫生—眼科]