MIM与VEGF在胃癌中的表达及其预后意义的研究  

Expression of MIM and VEGF and their prognostic significance in gastric carcinoma

作　　者：陈义钢[1] 柳珂[2] 朱荣[3] 于观贞[2] 丁厚中[3] 

机构地区：[1]江苏大学临床医学院,镇江江苏212013 [2]第二军医大学,上海200433 [3]江苏大学附属昆山第一人民医院,昆山江苏215300

出　　处：《中国现代医学杂志》2011年第14期1615-1619,共5页China Journal of Modern Medicine

基　　金：江苏省卫生厅科技基金(No:H200844)

摘　　要：目的检测MIM(missing in metastasis)和血管内皮细胞生长因子(vascular endothelial growth factor,VEGF)在胃癌中的表达,并探讨其变化与胃癌病理参数及预后的关系。方法在含有282例胃癌标本的组织芯片上,利用免疫组织化学检测MIM和VEGF在胃癌和胃正常组织中的表达,并统计分析相关结果与胃癌临床参数和预后的关系。结果 MIM在胃癌中阴性表达率分别为66.3%,VEGF在胃癌中阳性表达率为64.5%。MIM的阴性表达与淋巴结转移(阳性)、肿瘤分化程度(低分化)、TNM分期(晚期)有关;VEGF的阳性表达和患者年龄(>60岁)、肿瘤部位(贲门、胃底)和肿瘤分化程度(低分化)有关。Cox模型结果显示,MIM和VEGF是胃癌独立的预后因素。结论 MIM和VEGF可能是胃癌预后的重要影响因素,MIM可作为胃癌治疗的新靶点。【Objective】 To investigate expression of MIM（missing in metastasis） and VEGF（vascular endothelial growth factor） and their prognostic significance in gastric carcinoma.【Methods】 Tissue microarray blocks containing gastric tumor specimens from 282 patients were constructed.Expressions of MIM and VEGF in these specimens were analyzed using immunohistochemical（IHC） studies.【Results】 IHC showed that negative expression rate of MIM in gastric cancer was 66.3%.Negative MIM expression was significantly associated with advanced TNM stages,presence of lymph node metastases,poorly degree of tumor differentiation（P 0.05）.The rate of VEGF positive expression was 64.5%.The over expression of VEGF had a significant relationship with age（60 y）,higher tumor location and poorly differentiation（P 0.05）.According to the Cox proportional hazards model,MIM and VEGF expression were correlated with prognosis.There were no correlation between MIM and VEGF.【Conclusion】 The results suggested MIM and VEGF may play a crucial role in the development and progression of gastric cancer.MIM and VEGF may be regarded as the potential molecular targets for therapy.

关 键 词：胃癌 MIM 血管内皮细胞生长因子 

分 类 号：R735.2[医药卫生—肿瘤]