电针对佐剂性关节炎大鼠下丘脑中NF-KB表达的影响  

The Influence of Electric-acupuncture on Hypothalamus Nucleus NF-KB Amounts with Adjuvant-Induced Arthritis of Rats

作　　者：乔云英[1] 吴富东[1] 王健[1] 崔晓鲁[1] 刘丛丛[1] 朱新龙[1] 

机构地区：[1]山东中医药大学,山东济南250014

出　　处：《中华中医药学刊》2011年第6期1260-1262,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30772829)

摘　　要：目的:观察电针对佐剂性关节炎(AA)大鼠NF-KB在下丘脑表达的影响。探讨电针的镇痛及免疫调节作用。方法:将大鼠随机分为3组,即空白组、模型组及模型加电针组。用免疫组化方法检测各组下丘脑NF-KB(P65)的表达。结果:在模型组AA大鼠下丘脑中活化的NF-KB明显增多;与空白组比较有显著性差异。电针组较模型组NF-KB的表达减少,与模型组比较有显著性差异。结论:针刺可通过抑制活化的NF-KB在下丘脑的表达,调节NF-KB活性。针刺镇痛抗炎可通过NF-KB这一环节起到关键作用。Objective：To observe the influence of electric-acupuncture on hypothalamus Nucleus NF-KB amounts with adjuvant-induced arthritis of rats.To probe the analgesia and immunication of electric-acupuncture.Methods：divide the rats with 3 groups,blank,model and electric-acupuncture;use different methods to treat.after the experiment use immunication methods to detect the amounts of NF-KB on each hypothalamus nucleus.Results：in the model group there are more NF-KB active than blank group.after acupuncture,the NF-KB decreased.Conclusion：Acupuncture has the function of anti-inflammatory and analgesia through the link of regulate the activity of NF-KB.

关 键 词：电针 佐剂性关节炎 下丘脑 NF-KB 

分 类 号：R245[医药卫生—针灸推拿学]