中国人群无症状脑梗死发病情况调查及其相关危险因素分析  

Prevalence and risk factors of silent cerebral infarction in a Chinese population

作　　者：乙成成[1] 张颖秋[1] 刘雯雯[1] 郭志军[1] 殷仁富[1] 

机构地区：[1]第二军医大学长征医院贵宾诊疗科,上海200003

出　　处：《第二军医大学学报》2011年第5期537-540,共4页Academic Journal of Second Military Medical University

摘　　要：目的观察健康体检人群无症状脑梗死(silent cerebral infarction,SCI)的患病率、影像学特点,分析其相关危险因素。方法连续性收集第二军医大学长征医院贵宾诊疗科2006年5月至2010年3月行头颅磁共振(MRI)常规检查的1008例健康体检者,比较不同性别、年龄组间SCI患病率,概括其病灶特点,采用统计学方法分析各常见危险因素与SCI相关性。结果共发现328例SCI患者,患病率为32.5%,其中83.4%缺血灶为腔隙性脑梗死,好发于额叶、半卵圆中心、基底节区和侧脑室周围白质。单因素和多因素Logistic回归分析发现:年龄、高血压、糖尿病、低密度脂蛋白胆固醇、脂蛋白α、尿酸和颈动脉内中膜厚度在SCI和非SCI患者之间的差异有统计学意义,而且是SCI的独立危险因素。结论中国人群SCI发病率并不低,应引起重视并控制其危险因素。Objective To observe the prevalence,image findings and risk factors of silent cerebral infarctions（SCI） in healthy subjects undergoing physical examination.Methods A total of 1,008 consecutive subjects,who underwent brain MRI as part of their routine health check from May 2006 to March 2010,were included in the present study.The prevalences of SCI were compared in subjects of different ages and sexes,and the imaging features of the ischemic lesions were summarized.Statistical analysis was performed to assess the association of SCI with common risk factors.Results We identified 328 subjects who had SCI on MRI,with the prevalence being 32.5%,and we also found that 83.4% of the ischemic lesions were lacunar infarcts and mainly located in the frontal lobe,centrum semiovale,basal ganglia,and periventricular white matter.Univariate and multivariate logistic analyses showed that the age,hypertension,diabetes mellitus,low-density lipoprotein cholesterol,lipoprotein α,uric acid and carotid intima-media thickness were statistically significant between SCI and non-SCI patients,and they were the independent factors of SCI.Conclusion SCI is common in Chinese population,and more attention is needed for control of its risk factors.

关 键 词：无症状性脑梗死 磁共振成像 危险因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]