多层螺旋CT灌注成像技术在诊断肾肿瘤中的临床应用  

Clinical Application in the Diagnosis of Renal Tumors with Multi-slice Spiral CT Perfusion Imaging

作　　者：马娅琼[1] 徐香玖[2] 黄刚[2] 毛泽庆[2] 左晓娜[2] 王亚群[2] 

机构地区：[1]兰州大学医学院,甘肃兰州730000 [2]甘肃省人民医院放射科

出　　处：《实用放射学杂志》2011年第5期743-746,共4页Journal of Practical Radiology

摘　　要：目的 探讨多层螺旋CT（MSCT）灌注成像在肾肿瘤定性及肾癌临床分期中的应用价值.方法 回顾性分析经病理证实的28 例肾透明细胞癌（分Ⅰ～Ⅳ期）、20例肾错构瘤的多层螺旋CT 灌注成像结果,对肿瘤感兴趣区血流量（BF）、血容量（BV）、平均通过时间（MTT） 与表面通透性（PS）值进行统计学分析,研究其规律性.结果 （1）正常肾皮质BV/A 和BF值明显高于肾透明细胞癌和错构瘤（P＜ 0.01）;肾透明细胞癌BV/A和BF值明显高于肾错构瘤（P＜ 0.01）;正常肾皮质及肾透明细胞癌PS值明显高于肾错构瘤组（P＜ 0.01）.（2）肾透明细胞癌Ⅱ期、Ⅲ～Ⅳ期BV/A值、BF值与PS值明显高于肾透明细胞癌Ⅰ期患者（P＜0.05）;肾透明细胞癌Ⅱ期与Ⅲ～Ⅳ期之间相比较,BV/A值与PS值呈上升趋势,前者有统计学意义（P＜0.05）,BF值呈下降趋势,比较无统计学意义（P＞0.05）.（3）3组之间MTT值比较无统计学差异.结论 肾脏肿瘤MSCT灌注参数具有一定的规律,在肾肿瘤的诊断中有重要的临床应用价值.Objective To study the applied value of MSCT perfusion imaging in qualitative diagnosis of renal tumors and the clinical staging of renal carcinoma. Methods MSCT perfusion imaging data of 28 cases with renal clear cell carcinoma（sub [ IV period） and 20 cases with renal angiomyolipoma confirmed by pathology were retrospectively analysed,including blood flow{BF）, blood volume（BV） ,permeability surface（PS） and mean transit time（MTT） in the region of interest. Results （1）The values of BV/A（BV of aorta） and BF in the normal renal cortex were higher than that of the renal clear cell carcinoma and angiomyolipoma （P〈0.01）. The values of BV/A and BF in renal clear cell carcinoma were higher than that of renal angiomyolipoma（ P〈0.01 ）. The values of PS in normal renal cortex and renal clear cell carcinoma were higher than that of the renal angiomyolipoma（P〈〈0.01）. （2）The values of BV/A,BF and PS of the renal clear cell carcinoma in stage II, III -- IV were higher than that in stage I（P〈0.05）. From stage II to stage III -IV of renal clear cell carcinoma,the values of BV/A and PS were of rise（P〈0.05）,while the values of BF were of rise,but had no significant difference（P〉0.05）. （3）The values of MTT between the three groups were no of significant difference. Conclusion MSCT perfusion imaging has important clinical value in the diagnosis of renal tumors in that it has certain laws in perfusion pa rameters.

关 键 词：肾 肾透明细胞癌 肾错构瘤 体层摄影术 X线计算机 

分 类 号：R737.11[医药卫生—肿瘤] R814.42[医药卫生—临床医学]