肿瘤转移抑制蛋白在肝癌中的表达及其意义  

A study on the expression of MTSSI in hepatocellular carcinoma

作　　者：王鼎[1] 徐美荣[1] 朱建伟[1] 

机构地区：[1]南通大学附属医院普外科,江苏省226001

出　　处：《中华普通外科杂志》2011年第5期410-413,共4页Chinese Journal of General Surgery

基　　金：国家自然科学基金资助项目（30771126）;教育部回国留学人员基金资助项目（2008-890）;江苏省自然科学基金资助项目（BK2006058）

摘　　要：目的探讨肿瘤转移抑制蛋白1（metastasis suppressor1，MTSS1）在肝癌组织，肝硬化组织，正常肝组织中的表达及其意义。方法采用免疫组织化学检测MTSS1在肝癌组织，肝硬化组织，正常肝组织中的表达，并用单因素分析表达与临床病理因素的关系。用Spearman等级相关分析MTSS1表达水平与肝癌患者TNM分期的关系。对肝癌患者进行5年生存随访，采用Kaplan—Meier生存曲线分析。结果肝癌组织MTSS1表达水平与正常肝组织比较，差异有统计学意义（U=168．000，P〈0．05）；肝癌组织比肝硬化组织高，二者比较差异有统计学意义（U=106．000，P〈0．05）；MTSS1表达水平与肝癌患者的TNM分期、有无血管侵袭和肿瘤包膜有关（分别U=259．000，258．500，202．000，均P〈0．05），与肝癌患者的年龄、性别、肿瘤大小、AFP水平、乙肝表面抗原无关（P〉0．05）。MTSS1表达水平与临床TNM分级间呈负相关，即临床TNM分级越早期所对应的MTSS1表达水平越高（rs=-0．383，P〈0．05）。MTSS1阳性表达患者5年生存率明显低于MTSS1阴性及弱阳性表达患者，差异有统计学意义（分别34．1％，52．3％，x2=6．386，P〈0．05）。结论MTSS1高表达可能在早期肝癌进展中发挥重要作用，预示预后不良。Objective To explore the expression and significance of MTSS1 （metastasis suppressor 1 ） in hepatocellular carcinoma. Methods MTSS1 expression was detected by immunohistochemistry in hepatocellular carcinoma, liver cirrhosis and normal liver tissues. Single-factor analysis was used to study the relationship with clinicopathological factor. Correlations between MTSS1 expression and TNM stage were analyzed with Spearman rank correlation analysis. Postoperative 5-year survival was evaluated using Kaplan- Meier survival curve analysis. Results The expression of MTSS1 in hepatocellular carcinoma was higher than normal liver tissue （ U =168.000, P 〈 0. 05 ）, and liver cirrhotic tissue （ U = 106. 000, P 〈 0.05 ） ; MTSS1 expression was correlated with TNM stage of hepatocellular carcinoma patients, lymph vascular invasion and tumor capsule （separately U = 259. 000,258. 500,202. 000, all P 〈 0. 05 ）. MTSS1 expression in hepatocellular carcinoma was not correlated with patients age, gender, tumor size, AFP level, and hepatitis B surface antigen. MTSS1 expression and TNM stage of liver cancer patients was negatively correlated （ rs = - 0. 383, P 〈 0. 05 ）. Postoperative 5-year survival of hepatocellular carcinoma patients with MTSS1 positive expression was significantly poorer than patients with negative and weakly positive expression （ respectively 34. 1% and 52. 3%, X2 = 6. 386, P 〈 0. 05 ）. Conclusions MTSS1 high expression may play an important role in the early hepatocellular carcinoma progression, indicating a poor prognosis.

关 键 词：癌 肝细胞 基因表达 肿瘤转移抑制蛋白1 预后 

分 类 号：R735.7[医药卫生—肿瘤]