核因子-κB在三阴性乳腺癌中的表达及其意义  

The expression of nuclear factor kappa B in triple negative breast cancer and its clinical significance

作　　者：罗湘[1] 史艳侠[2,3] 李志铭[2,3] 孙月丽[2,3] 姜文奇[2,3] 

机构地区：[1]萍乡市人民医院肿瘤科,江西萍乡337000 [2]华南肿瘤学国家重点实验室,3510060 [3]中山大学肿瘤防治中心肿瘤内科,510060

出　　处：《临床肿瘤学杂志》2011年第5期417-420,共4页Chinese Clinical Oncology

摘　　要：目的探讨核因子-κB(NF-κB)在三阴性乳腺癌组织中的表达及其与临床病理特征和预后的关系。方法应用免疫组化法PV-6000二步法检测137例三阴性乳腺癌和132例非三阴性乳腺癌患者癌组织NF-κB的表达,分析其与临床病理特征和预后之间的关系。结果 137例三阴性乳腺癌组织中的NF-κB阳性表达率为73.7%(101/137),明显高于非三阴性乳腺癌的46.2%(61/132),差异有统计学意义(P=0.000)。在137例三阴性乳腺癌中,NF-κB表达与VEGF、p53、组织分级、淋巴结转移、5年无病生存率和5年总生存率有关(P<0.05);而在132例非三阴性乳腺癌中,NF-κB表达仅与VEGF、淋巴结转移、5年无病生存率相关(P<0.05)。结论 NF-κB在三阴性乳腺癌中表达率高,并可作为三阴性乳腺癌的预后指标。Objective To explore the expression of nuclear factor kappa B（NF-κB） and its relationship with clinicopathological parameters in triple-negative breast cancer（negative estrogen receptor,negative progesterone receptor and negative HER-2）.Methods Immunohistochemical assays were performed to determine the expression of NF-κB in 137 cases of triple-negative breast cancer and 132 cases of non-triple negative breast cancer.The relationships between immunohistochemicaI results and clinicopathological data and prognosis were analyzed.Results The positive expression rate of NF-κB was 73.7%（101/137） in triple negative breast cancer,which was higher than 46.2%（61/132）in non-triple negative breast cancer,with statistical significance（P=0.000）.It correlated to VEGF（P=0.024）,p53（P=0.0486）,tumor grade（P=0.028）,node status（P=0.038）,5-year disease free survival（P=0.014） and 5-year overall survival（P=0.008） in triple negative breast cancer,but only related to VEGF（P=0.038）,node status（P=0.040） and 5-year disease free survival（P=0.021）in non-triple negative breast cancer.Conclusion The expression of NF-κB is high,and it is a significant prognostic factor in triple-negative breast cancer.

关 键 词：乳腺肿瘤 核因子-ΚB 临床病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]