原发性胃淋巴瘤与原发性大肠淋巴瘤临床特点的差异分析  

The differences of clinical features between primary gastric lymphoma and primary colorectal lymphoma

作　　者：孙姚[1] 万娟[1] 李媛媛[1] 李国华[1] 

机构地区：[1]南昌大学第一附属医院消化科,南昌330006

出　　处：《临床肿瘤学杂志》2011年第5期449-451,共3页Chinese Clinical Oncology

摘　　要：目的了解原发性胃淋巴瘤和大肠淋巴瘤临床特点的差异。方法回顾性调查1999年1月至2009年6月间在我院住院且确诊为原发性胃肠道淋巴瘤（PGIL）患者,分析胃淋巴瘤与大肠淋巴瘤之间在发病年龄、性别、内镜下表现、病理特征等方面的差异。结果共79例患者诊断为PGIL,其中原发胃淋巴瘤48例,原发大肠淋巴瘤31例,两组均以腹痛、贫血为主要表现。与原发大肠淋巴瘤相比,原发胃淋巴瘤合并腹胀较多见,而腹部包块少见,但在性别和病程方面两组无明显差异（P〉0.05）。原发胃淋巴瘤的平均发病年龄为（55.7±14.7）岁,大于原发大肠淋巴瘤的（35.1±17.6）岁（P〈0.01）。原发性胃淋巴瘤Ⅲ~Ⅳ期患者较多,以B系淋巴瘤为主,多数均行根治性手术＋化疗;而原发性大肠淋巴瘤Ⅱ期较多见,虽然B系占主要部分,但T系比例多于胃淋巴瘤（10.1%vs.1.3%,P〈0.05）,且行姑息手术治疗的比例高（32.3%vs.6.3%,P〈0.01）。原发性胃淋巴瘤和大肠淋巴瘤内镜下诊断率分别为26.3%和14.3%,内镜活检标本诊断率分别为57.9%和60.4%。结论原发性胃淋巴瘤和大肠淋巴瘤在发病年龄、临床症状、临床分期、治疗方法上均有差异,且内镜下诊断率偏低。Objective To research the differences of clinical features between primary gastric lymphoma and primary colorectal lymphoma.Methods Differences in age,gender,endoscopic manifestations,pathological characteristics between primary gastric lymphoma and primary colorectal lymphoma were studied retrospectively in patients who were diagnosed as primany gastrointestinal lymphoma（PGIL） from January 1999 and June 2009.Results Seventy-nine PGIL patients were enrolled in the study,among them,there were forty-eight primary gastric lymphoma patients and thirty-one primary colorectal lymphoma patients.The most common symptoms were abdominal pain and anemia.Compared with primary colorectal lymphoma,more abdominal distension symptom and less abdominal mass were in primary gastric lymphoma.There was no significant difference in sex ratio and disease duration（P0.05）.Average onset age of primary gastric lymphoma was significantly higher than that of primary colorectal lymphoma（55.7±14.7 vs.35.1±17.6,P0.01）.In primary gastric lymphoma,the most clinical stage was Ⅲ-Ⅳ,the vast majority was B cell lymphoma and the an ventional therapies were radical surgery and chemotherapy.But the most clinical stage was Ⅱ in primary colorectal lymphoma,the vast majority was B cell lymphoma too,but the incidence rate of T cell lymphoma was more than that of gastric lymphoma（10.1% vs.1.3%,P0.05）,more patients with primary colorectal lymphoma were treated with palliative surgery comparied those with primary gastric lymphoma（32.3% vs.6.3%,P0.01）.The endoscopic and the endoscopic biopsy specimens diagnostic rates of primary gastric lymphoma and colorectal lymphoma were 26.3%,14.3% and 57.9%,60.4%,respectively.Conclusion There were differences in age,clinical symptoms,clinical stage,treatments between primary gastric lymphoma and primary colorectal lymphoma.The endoscopic diagnosis rate of those diseases was low.

关 键 词：原发性胃淋巴瘤 原发性大肠淋巴瘤 临床特点 

分 类 号：R733[医药卫生—肿瘤]