喉癌中肝细胞再生磷酸酶-3的表达及与微血管密度的相关性  

The Expression and Significance of Phosphatase of Regenerating Liver-3 and Microvessel Density in Laryngeal Squamous Cell Carcinoma

作　　者：胡海丽[1] 董雪蕾[1] 田秀芬[2] 

机构地区：[1]郑州大学第三附属医院耳鼻喉科,450052 [2]郑州大学第一附属医院耳鼻喉科

出　　处：《天津医药》2011年第6期496-498,共3页Tianjin Medical Journal

基　　金：郑州市科技局普通攻关2008资助项目(项目编号:083SGYS33261-13)

摘　　要：目的：探讨在喉鳞状细胞癌中肝细胞再生磷酸酶-3（PRL-3）和微血管密度（MVD）的相关性。方法：采用免疫组化SABC法检测69例喉鳞状细胞癌组织和25例相应癌旁组织中PRL-3的表达情况,并用CD105标记MVD,研究PRL-3的表达及MVD计数与喉鳞癌临床病理特征的关系,采用Spearman等级相关分析PRL-3表达与MVD的相关性。结果：PRL-3在癌组织中的阳性表达率（65.22%）高于癌旁组织（8%）,差异有统计学意义（P〈0.01）。癌组织中有淋巴结转移患者的PRL-3阳性率和MVD计数明显高于无淋巴结转移患者,病理分期为Ⅲ~Ⅳ期的PRL-3和MVD高于Ⅰ-Ⅱ期,差异均有统计学意义（P〈0.05）。PRL-3的表达与MVD计数呈正相关（r=0.811,P〈0.01）。结论：PRL-3可能作为一种新的肿瘤标志物来监控喉鳞状细胞癌的发生、浸润和转移。Objective：To evaluate the role of phosphatase of regenerating liver-3（PRL-3） and microvessel density （MVD） in laryngeal squamous cell carcinoma, and their relationship thereof. Methods： The expression level of PRL-3 was detected by immmuno-histochemical SABC method in tissue samples of 69 laryngeal carcinoma and 25 corresponding adjacent tissues. MVD was marked by CD105. The relationship between expression of PRL-3, the count of MVD and the clinicopathologic parameters of laryngeal squamous cell carcinoma was investigated. Results： The positive rate of PRL-3 was significantly higher in laryngeal squamous cell carcinoma （65.22%） than that of corresponding adjacent tissues （8%, P 〈 0.01）. The positive expression of PRL-3 and count of MVD were significantly higher in lymph-node metastasis group than those in no-metastasis group （P 〈 0.05）. The expression of PRL-3 and MVD were significantly higher in Ⅲ- Ⅳ pathological staging than those of stage Ⅰ-Ⅱ （P 〈 0.05）. The expression of PRL-3 was positively correlated with MVD （r = 0.811, P 〈 0.01）. Conclusion：PRL-3 may be used as a new tumor marker in occurrence, invasion and metastasis of laryngeal squamous cell carcinoma.

关 键 词：肿瘤 鳞状细胞 喉肿瘤 癌 磷酸单酯水解酶类 新生血管化  病理性 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]