肿瘤坏死因子A-863C/A基因型与慢性牙周炎和冠心病的相关性研究  

Research of association between tumor necrosis factorA-863C/A genotype and chronic periodontitis and coronary heart disease

作　　者：张蕾[1] 钟良军[1,2] 张琼[1] 孙大磊[1] 张源明[3] 

机构地区：[1]新疆医科大学第一附属医院口腔医学系,乌鲁木齐830054 [2]杭州师范大学临床医学院 [3]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054

出　　处：《口腔医学》2011年第5期261-264,共4页Stomatology

基　　金：国家自然科学基金(30860314)

摘　　要：目的探讨肿瘤坏死因子(TNF)A-863C/A基因型与慢性牙周炎和冠心病的相关性。方法采用聚合酶链反应-限制性片段长度多态性法分别检测慢性牙周炎(Chronic periodontitis,CP)组、冠心病(Coronary heart Disease,CHD)组、慢性牙周炎合并冠心病(CP+CHD)组以及健康对照组(Healthy controls,HC)组TNFA-863位点的基因型。结果在CHD组和CP+CHD组TNFA-863CC基因型和C等位基因频率均高于HC组(P值均小于0.017),并且CP+CHD组中男性的TNFA-863CC基因型和C等位基因频率高于女性(P值均等于0.000,OR值分别为4.292和5.562)。结论 TNFA-863CC基因型和C等位基因与冠心病发病相关,可能是冠心病的易感基因;同时它也可能是发生CP合并CHD的易感基因,并且携带TNFA-863CC基因型和C等位基因的男性更好发。Objective To investigate the association between the tumor necrosis factor A（TNFA）-863C/A genotype and chronic periodontitis and coronary heart disease.Methods Polymerase chain reaction-restriction fragment length polymorphism was used to detect the genotypes of TNFA-863C/A in four groups as follows：Chronic Periodontitis（CP）group,Coronary Heart Disease（CHD）group,CP＋CHD group and Healthy Controls（HC）group.Results The frequences of TNFA-863CC genotype and allele C in CHD group and CP＋CHD group were higher than those in HC group（All of their P0.017）.Furthmore,in CP＋CHD group,the frequences of TNFA-863CC genotype and allele C in male patients were significantly higher than those in female patients（both of their P=0.000,OR=4.292 and 5.562 respectively,95%IC：1.884-9.777 and 3.185-9.713 respectively）.Conclusions TNFA-863CC genotype and allele C may be associated with susceptibility to CHD,and they also may be the susceptive gene to CP companied CHD,especially in male patients.

关 键 词：慢性牙周炎 冠心病 肿瘤坏死因子 基因型 

分 类 号：R739.8[医药卫生—肿瘤]