维生素D受体基因TagⅠ和BsmⅠ位点单核苷酸多态性与种植体周围炎的易感性研究  

Association of Peri-implantitis with Vitamin D Receptor Gene Polymorphism(TagI,BsmI)

作　　者：刘琼[1] 黄建生[1] 徐平平[1] 刘天涛[1] 戚娟娟[1] 黄晓虹[1] 刘丹[1] 

机构地区：[1]南方医科大学附属口腔医院.广东省口腔医院特诊中心,广东广州510280

出　　处：《广东牙病防治》2011年第5期249-253,共5页Journal of Dental Prevention and Treatment

摘　　要：目的研究维生素D受体(vitamin D receptor,VDR)基因TagⅠ和BsmⅠ位点单核苷酸多态性与种植体周围炎易感性的关系。方法采用病例对照试验设计,收集种植体周围炎组及无种植体周围炎组各50例,应用聚合酶链反应—限制性内切酶片段长度多态性分析方法研究2组VDRTagⅠ和BsmⅠ位点的基因型以及等位基因分布特点,并探讨其与种植体周围炎的相关性。结果 VDR基因BsmⅠ位点各基因型(χ2=3.184,P=0.074)和等位基因频率(χ2=3.269,P=0.071)在2组间分布差异无统计学意义。VDR基因TagⅠ位点主要基因型为TT纯合子和Tt杂合子,2种基因型(χ2=4.337,P=0.037)和T、t等位基因频率(χ2=3.907,P=0.048)在2组的分布差异具有统计学意义。TT型在种植体周围炎组中较为多见。结论避免吸烟、牙周炎病史等混杂因素后,种植体周围炎与VDRTaqI位点单核苷酸多态性间存在遗传相关性,尚不能认为与BsmⅠ位点的多态性相关。Objective To investigate the association between vitamin D receptor polymorphism （TagI, BsmI） and peri-implantitis. Methods The genotype and allele distributions of vitamin D receptor in a case-control study involving 50 patients with peri-implantitis （ M group） and 50 health controls （ N group） were analyzed by PCR-restriction fragment length polymorphism. Results A different distribution （P 〈 0.05 ） of Taql I/DR genotypes was found in M group compared with N group, but not Bsml VDR. In particular, the prevalence of TT VDR genotypes in M group was significantlyhigher than in N group. Conclusion Excluded some influence factors, such as smoking and periodontitis, the results demonstrateds that a genetic association of periimplantitis with Taql VDR polymorphism and, but not with BsmI VDR.

关 键 词：种植体周围炎 维生素D受体 基因多态性 牙种植/副作用 维生素D 多态现象 遗传学 

分 类 号：R394[医药卫生—医学遗传学]