RASAL1基因在胃癌组织中的表达及其临床意义  

Clinical significance of expression of RASAL1 in gastric cancer

作　　者：夏挺松[1] 陈洪[2] 钱建忠[3] 徐洪明[3] 陆枫林[2] 

机构地区：[1]东南大学附属江阴医院消化科,江苏省江阴市214400 [2]东南大学附属中大医院消化科,江苏省南京市210009 [3]东南大学附属江阴医院病理科,江苏省江阴市214400

出　　处：《世界华人消化杂志》2011年第13期1403-1407,共5页World Chinese Journal of Digestology

基　　金：江苏省自然科学基金资助项目;No.BK2008301~~

摘　　要：目的:探讨Ras蛋白激活物类似物-1(RASAL1)基因在胃癌组织中的表达情况及临床意义.方法:应用免疫组织化学SP法分别检测50例正常组织、50例低级别上皮内瘤变组织、50例高级别上皮内瘤变组织+早期胃癌组织及50例进展期胃癌组织中RASAL1基因的表达,并结合其临床病理资料进行综合分析.结果:RASAL1基因在正常组、低级别上皮内瘤变组、高级别上皮内瘤变+早期胃癌组及进展期胃癌组的阳性率分别为94.0%(47/50)、70.0%(35/50)、42.0%(21/50)及18.0%(9/50),各组之间的差异有统计学意义(均P<0.05);各组RASAL1基因的表达与性别、年龄、生长部位等均无相关性;高级别上皮内瘤变组织+早期胃癌组和进展期胃癌组中RASAL1基因的表达与肿瘤大小、分化程度、浸润深度及淋巴结转移有相关性(均P<0.05).结论:RASAL1基因的低表达与胃癌的发生及进展有密切关系,检测胃癌组织中RASAL1的表达可反映肿瘤大小、分化程度、浸润深度及有无淋巴结转移.AIM：To detect the expression of Ras protein activator like 1（RASAL1）in gastric cancer and to analyze its clinicopathological significance.METHODS：Immunohistochemistry was used to detect RASAL1 expression in 50 cases of normal gastric tissue,50 cases of low intraepithelial neoplasia,50 cases of high intraepithelial neoplasia and early gastric carcinoma,and 50 cases of advanced gastric carcinoma.The correlation between RASAL1 expression and clinicopathological features of gastric cancer was then analyzed.RESULTS：The positive rate of RASAL1 expression had significant differences among each group.The positive rate of RASAL1 expression was 94.0%（47/50）in normal gastric tissue,70.0%（35/50）in low intraepithelial neoplasia,42.0%（21/50）in intraepithelial neoplasia and early gastric carcinoma,and 18.0%（9/50）in advanced gastric carcinoma.The positive rate of RASAL1 expression was not correlated with sex,age,or tumor site,but was correlated with tumor size,differentiation,invasive depth and lymph node metastasis in high intraepithelial neoplasia and early gastric carcinoma and advanced gastric carcinoma（all P0.05）.CONCLUSION：Decreased expression of RASAL1 correlates with the development of gastric cancer.The lower expression of RASAL1 underlies bigger tumor size,lower degree of differentiation,deeper invasion,and more metastatic lymph nodes in patients with gastric cancer.

关 键 词：Ras蛋白激活物类似物-1 胃癌 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]