STAT3、MMP-2在肝细胞癌中的临床意义  

Expressions and clinical significances of STAT3 and MMP-2 in hepatocellular carcinoma

作　　者：袁晟光[1] 苏如葵[1] 廖维甲[1] 覃理灵[1] 

机构地区：[1]桂林医学院附属医院,541001

出　　处：《实用医学杂志》2011年第12期2142-2144,共3页The Journal of Practical Medicine

基　　金：广西高校优秀人才资助计划基金资助(编号:No.RC2007027);2007年度广西医疗卫生自筹经费课题基金资助(合同号:Z2007203)

摘　　要：目的:探讨STAT3与MMP-2在肝细胞癌中的临床意义。方法:应用免疫组化法检测肝细胞癌组织及癌旁组织中STAT3与MMP-2的表达,分析STAT3、MMP-2与病理分化、TNM分期、生存期的关系。结果:STAT3与MMP-2在肝癌组织表达阳性率分别为71.4%、73.2%,癌旁组织中阳性率分别57.1%、80.4%,肝癌组织STAT3与癌旁组织中MMP-2的表达呈正相关(r=0.483,P<0.01)。结论:STAT3与MMP-2参与肝癌的发生发展过程,可作为评估肝细胞癌转移、侵袭及术后预后的指标。Objective To explore the expressions and clinical prognostic significances of STAT3 and MMP- 2 in hepatocellular carcinomas tissue （HCC）. Methods Expressions of STAT3 and MMP-2 in 56 specimens of HCC and 56 specimens of adjacent tissues of HCC were investigated by immunohistochemistry,and the relationships among STAT3 and MMP-2 and pathological differentiation, survival, and clinical feature were analyzed. Results The positive expression rates of STAT3 and MMP-2 in HCC were 71.4% and 73.2%, and those in adjacent tissues of HCC were 57.1% and 80.4%, respectively. There was a positive relationship between the expression of STAT3 in HCC and that of MMP-2 in adjacent tissues of HCC （r = 0.483,P 〈 0.01）. Conclusion STAT3 and MMP-2 may take part in the occurrence and development of HCC, and may be used as indicators for metastasis, infestation, and prognosis after operation of HCC.

关 键 词：癌 肝细胞 STAT3 MMP-2 

分 类 号：R735.7[医药卫生—肿瘤]