胃癌及乳癌对化疗药物敏感性的测定  

SENSITIVITY TEST OF HUMAN GASTRIC CANCER AND BREAST CANCER TO CHEMOTHERAPY

作　　者：王秋波[1] 鲁迎年[1] 王静[1] 张艳丽 

机构地区：[1]青岛医学院免疫学教研室

出　　处：《青岛医学院学报》1999年第2期100-101,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨胃癌、乳癌对常用化疗药物的反应性，筛选针对个体的化疗药物，为临床用药提供依据。②方法采用噻唑蓝（ＭＴＴ）法，对肿瘤组织进行５－氟尿嘧啶（５－ＦＵ）、顺铂（ＤＤＰ）、氨甲喋呤（ＭＴＸ）、丝裂霉素（ＭＭＣ）、长春新碱（ＶＣＲ）、平阳霉素（ＰＹＭ）、足叶乙甙（ＶＰ－１６）敏感性测定。③结果７种化疗药物对胃癌、乳癌抑制率不同，其中ＤＤＰ，５－ＦＵ，ＰＹＭ，ＶＣＲ，ＭＭＣ对胃癌抑制率较高；５－ＦＵ，ＰＹＭ，ＤＤＰ对乳癌抑制率较高。不同个体对化疗药物敏感性差异较大，胃癌病人对ＤＤＰ，５－ＦＵ，ＰＹＭ敏感者居多；乳癌病人对５－ＦＵ，ＰＹＭ敏感者居多。④结论不同肿瘤及同一肿瘤不同个体对化疗药物敏感性有显著差异。Objective\ To study the reactivity of human gastric cancer and breast cancer to chemotherapeutic agents and screen the sensitive drugs for individual.\ Methods\ The chemosensitivities of 24 human gastric cancer and 17 human breast cancer samples to 5 FU,DDP,MTX,MMC,VCR,PYM,VP 16 were determined by using tetrazolium based colorimetric assay ( MTT assay).\ Results\ DDP, 5 FU,PYM,VCR,MMC showed significant inhibitory effects for gastric cancer, and 5 FU,PYM,DDP showed significant inhibitory effects for breast cancer. The individual chemosensitivity was different. Most of gastric cancer samples were sensitive to DDP,5 FU,PYM, and breast cancer samples were sensitive to 5 FU,PYM.\ Conclusion\ Different neoplasms and different individual of the same neoplasm showed significant difference in chemosensitivity.

关 键 词：胃肿瘤 药物筛选 乳腺癌 药敏试验 

分 类 号：R735.205[医药卫生—肿瘤] R737.905[医药卫生—临床医学]