大鼠腹侧脑桥神经元NMDA受体和GABA受体在黑伯反射中的作用  

Role of NMDA and GABA receptors located in ventrolateral-pons neurons in Hering-Breuer reflex

作　　者：汪慧[1,2] 于书彦[2] 张衡[2] 

机构地区：[1]山东科技大学信息与电气工程学院山东省机器人与智能技术重点实验室,山东青岛266510 [2]山东大学医学院

出　　处：《山东医药》2011年第20期13-14,28,I0001,共4页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(60875068);科技部国际合作项目(2008DFR00560);青岛市科技局资助项目(10-3-4-2-2-jch)

摘　　要：目的探讨大鼠腹侧脑桥神经元上NMDA和GABA受体在黑伯反射中的作用。方法通过显微注射技术向大鼠腹侧脑桥内注射NMDA受体阻断剂D-2-氨基-5-磷酸基戊酸(D-AP5)和GABA受体阻断剂荷包牡丹碱(B IC),观察其对黑伯反射膈神经放电的影响。结果应用D-AP5削弱了黑伯反射的呼吸抑制效应,应用B IC增强了黑伯反射的呼吸抑制效应。结论存在于腹侧脑桥的由NMDA及GABA受体介导的突触传递参与了对黑伯反射强度的调节,但两者作用相反。Objective To investigate the role of NMDA and GABA receptors located in ventrolateral-pons（vl-pons） neurons in Hering-Breuer reflex（HBR） as simulated with electrical vagal stimulation.Methods Experiments were done on rats to observe the effects of NMDA receptor antagonist D-2-amino-5-phosphonovaleric acid（D-AP5） and GABA receptor antagonist bicuculline（BIC） on the phrenic nerve discharges in HBR by microinjecting the two antagonists into vl-pons.Results The HBR was weakened after microinjection of D-AP5 while it was strengthed after microinjection of BIC into vl-pons.Conclusion Neurotransmissions mediated by NMDA and GABA receptors in vl-pons are both involved in the modulation of HBR oppositely.

关 键 词：受体 NMDA GABA 腹侧脑桥 黑伯反射 大鼠 

分 类 号：Q473[生物学—生理学]