近红外光谱技术对胶质瘤大鼠优化散射系数的研究  

Measurement of reduced scattering coefficient of C6-glioma rats by near infrared spectroscopy technique

作　　者：郭凯[1] 杨天明[1] 钱志余[2] 张立国[1] 刘华亭[1] 

机构地区：[1]东南大学附属中大医院,南京210009 [2]南京航空航天大学

出　　处：《山东医药》2011年第20期17-19,共3页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30671997)

摘　　要：目的探讨应用近红外光谱技术测量C6荷瘤大鼠脑胶质瘤优化散射系数的特点。方法选取40只SD大鼠随机分为实验组和对照组,每组20只。将培养的C6细胞立体定向接种于SD大鼠的尾状核,MR I检查肿瘤生长至直径0.5～1.0 cm时作为实验组,正常大鼠作为对照组。利用稳态光纤光谱仪的微创光学探头测量各组的优化散射系数。结果胶质瘤组的优化散射系数低于对照组(P<0.05)。结论近红外光谱技术可以应用于胶质瘤的检测,其中优化散射系数是检测脑胶质瘤的良好指标。Objective To observe the characteristics of reduced scattering coefficient measurement of living C6-glioma rats by near infrared spectroscopy technique.Methods Forty SD rats were randomly divided into 2 groups,C6-glioma group and control group.C6 cells were injected in SD rat caudate nucleus by means of subculture of stereotactic inoculation.When the glioma had grown to 0.5～1.0 cm in diameter as experimental group by MRI detection.A specific designed fiber optical spectrum system was applied to measure the optical parameters（reduced scattering coefficient） in 20 C6-glioma rats compared to control group.Results Reduced scattering coefficient in experimental group was lower than that in control group（P0.05）.Conclusion The near infrared spectroscopy technique can be applied to detect the glioma,and reduced scattering coefficient can be used for the glioma quantification.

关 键 词：近红外光谱 胶质瘤 优化散射系数 

分 类 号：R739.4[医药卫生—肿瘤]